FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ple4
Open Close
General Information
Symbol
Dmel\ple4
Species
D. melanogaster
Name
FlyBase ID
FBal0013854
Feature type
allele
Associated gene
Dmel\ple
Associated Insertion(s)
Carried in Construct
Also Known As
ple14A82
Key Links
Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Neckameyer and White, 1993)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Deletion of approximately 500-700bp that deletes intron and maybe also exon sequences.

    (Neckameyer and White, 1993)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygotes show abnormal temperature-preference behaviour; their avoidance index against low temperatures is less than 34% of wild type, while their avoidance index against high temperatures is normal.

        (Bang et al., 2011)

        Heterozygotes have normal locomotor activity at 25oC.

        (Pendleton et al., 2002)

        ple+t8 rescues mutant embryos to viable adults. Some adults die attempting to free themselves from the pupal case, the greatest lethality occurs during the pharate adult stage. Adults that do eclose are paler than their ple+ siblings and they appear weaker in their movements with a tendency to drown in the food medium. Rescued larvae are normal in their response to both light and NaCl.

        (Neckameyer and White, 1993)

        Mechanical dechorionation and devitellinization of hemizygous and homozygous eggs leads to development of pharate larvae. These have complete lack of pigmentation of the cuticle, mouth hooks, spiracles and setae.

        (Budnik and White, 1987)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Other
        Statement
        Reference

        Ddc27, ple4 has cephalopharyngeal skeleton phenotype

        (Mace et al., 2005)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Ddc27 ; ple4 first instar larvae have almost no melanisation and sclerotisation of the head skeleton.

        (Mace et al., 2005)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        ple4 is rescued by ple+t8

        (Bang et al., 2011)

        ple4 is rescued by ple+t11

        (Neckameyer et al., 2001)
        Partially rescued by

        ple4 is partially rescued by ple+t8

        (Neckameyer et al., 2001)

        ple4 is partially rescued by ple+t8

        (Neckameyer and White, 1993)
        Comments

        The abnormal temperature-preference behaviour of ple4 flies (reduced avoidance index against low temperatures compared to wild type) is rescued by ple+t8.

        (Bang et al., 2011)

        ple+t8 rescues mutant embryos to viable adults.

        (Neckameyer and White, 1993)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Mutation leads to disruption of catecholamine synthesis without disrupting serotonin synthesis.

        (Budnik and White, 1987)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        References (12)