FB2026_02 , released June 18, 2026
Allele: Dmel\ple+t8
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General Information
Symbol
Dmel\ple+t8
Species
D. melanogaster
Name
FlyBase ID
FBal0065709
Feature type
allele
Associated gene
Dmel\ple
Associated Insertion(s)
Carried in Construct
P{ple+8}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Neckameyer and White, 1993)
wild_type
(Neckameyer and White, 1993)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Neckameyer and White, 1993)
wild_type
(Neckameyer and White, 1993)
Mutagen
in vitro construct
(Neckameyer and White, 1993)
Progenitor genotype
Carried in construct
P{ple+8}
Cytology
Description

8kb ple genomic SmaI-EcoRI fragment containing 1kb of 5' upstream and 1kb of 3' downstream sequences.

(Neckameyer and White, 1993)
Allele components
Component
Use(s)
Regulatory region(s)
ple
Encoded product / tool
ple
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3L:6,710,594..6,718,709 [-]
Linked to:
SmaI-EcoRI restriction fragment
Comment:

The position of the restriction fragment on the reference sequence was inferred by a FlyBase curator.

(Neckameyer and White, 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      ple+t8 rescues ple4

      (Bang et al., 2011)
      Partially rescues

      ple+t8 partially rescues ple2

      (Neckameyer et al., 2001)

      ple+t8 partially rescues ple4

      (Neckameyer et al., 2001)

      ple+t8 partially rescues ple2

      (Neckameyer and White, 1993)

      ple+t8 partially rescues ple4

      (Neckameyer and White, 1993)
      Comments

      The abnormal temperature-preference behaviour of ple4 flies (reduced avoidance index against low temperatures compared to wild type) is rescued by ple+t8.

      (Bang et al., 2011)

      ple+t8 rescues ple2 and ple4 mutants 100% through the larval stage, but adult rescue is less than 50%. Those adults that do eclose are paler and weaker than their wild-type siblings.

      (Neckameyer et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Fragment contains the necessary elements for correct temporal and spatial expression of the gene but may not contain all the sequences essential for quantitative expression.

      (Neckameyer and White, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ple+t8
      Name Synonyms
      Secondary FlyBase IDs
        References (3)