FB2026_02 , released June 18, 2026
Allele: Dmel\DdcRE
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General Information
Symbol
Dmel\DdcRE
Species
D. melanogaster
Name
FlyBase ID
FBal0002296
Feature type
allele
Associated gene
Dmel\Ddc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypermorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypermorphic allele - genetic evidence

Mutagen
spontaneous
natural population
Progenitor genotype
Cytology

Polytene chromosomes normal. not a duplication at either the cytological level or at the DNA level.

Description

Canton-S-like on the basis of restriction enzyme site polymorphisms.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dual phenotype of elevated DDC activity and increased resistance to dietary α methyl dopa relative to Oregon-R derived controls (DdcC). Specific DDC activity of newly eclosed adults 158% and DDC crossreacting material (CRM) 156% of the DdcC control. LD50 for α methyl dopa is about 0.4 mM vs. about 0.2 mM for the DdcC control. Gene dosage studies with Ddc+ and amd+ demonstrate that increased resistance to α methyl dopa is not the result of increased DDC activity. Thus, the dual phenotype is inferred to arise from a coordinated increase in Ddc+ activity and amd+ activity produced either by accumulated changes in a genetic element (or elements) in the close proximity to the Ddc and amd genes. Specific DDC activity of newly eclosed adult CyO/Ddc heterozygotes, as percentage of CyO/+ control: 158

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Sherald.

      Comments
      Comments

      Originally reported as being EMS-induced in Oregon-R but probably a Canton-S contaminant. Made coisogenic with DdcC strain.

      Coordinately increases the function of Ddc and amd. Mutation is not a duplication.

      (Wright et al., 1981)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DdcRE
      RE
      (Wright et al., 1981)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)