FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ddcts2
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General Information
Symbol
Dmel\Ddcts2
Species
D. melanogaster
Name
FlyBase ID
FBal0002299
Feature type
allele
Associated gene
Dmel\Ddc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

heat sensitive loss of function allele

Mutagen
Nature of the Allele
Allele class

heat sensitive loss of function allele

(Wright et al., 1982)
Mutagen
ethyl methanesulfonate
(Wright et al., 1982)
formaldehyde
(Wright et al., 1982)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease 1
      modeled by Hsap\SNCAUAS.cJa
      (Rousseaux et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ddcts2/Ddc7 and Ddcts2/Df(2L)TW130 adults raised at 18[o]C and then transferred to 25[o]C 4 days prior to infection show no difference in survival rates after infection with either E. coli or S. aureus compared to the survival rates of wild-type controls.

      (Davis et al., 2008)

      When Ddcts2 pharate adult tissue (derived from larvae reared at the permissive temperature until third instar and then shifted to the restrictive temperature) is incubated with dopamine in vitro, wild-type levels of melanisation are obtained.

      (Walter et al., 1996)

      Without heat shock individuals carrying P{Hsp70/Ddc} exhibit full suppression of the pupal cuticle colouration phenotype.

      (Shen et al., 1993)

      Homozygous larvae raised at the restrictive temperature (29oC) show a significant decrease in immune capacity compared to homozygous larvae raised at the permissive temperature (20oC), with less than 9% melanotic encapsulation of L.boulardi eggs 48 hours after parisitization for larvae raised at 29oC, compared to approximately 80% encapsulation for larvae raised at 20oC.

      (Nappi et al., 1992)

      Recently eclosed hemizygous adults shifted to 29oC have an underpigmented cuticle which darkens on aging, producing abnormally dark adults with obvious concentrations of melanisation in the joints of the legs and axillae of the wings. The bristles of hemizygous adults shifted to 29oC during metamorphosis are pale and straw coloured. Hemizygous pupal cases are dark grey and flexible.

      (Bishop and Wright, 1987)

      Few homozygotes eclose at 22oC and exhibit an incomplete sclerotization phenotype.

      (Black et al., 1987)

      Homozygotes are lethal at 25oC or 29oC and viable at 22oC. Adult escapers have a pale unpigmented cuticle, unpigmented bristles, melanization of joints on the leg and axillae of the wing. Phenotype can be rescued by introduction of P{DdcP10} construct.

      (Marsh et al., 1985)

      At 25oC pupae are yellow-green.

      (Scholnick et al., 1983)

      Shows the escaper phenotype (incomplete sclerotinization) when transheterozygous with Df(2L)TW130. Developmental time is protracted by at least four days.

      (Wright et al., 1982)

      Shows conventional temperature sensitive effects on viability, though does not show sterility at 30oC.

      (Wright et al., 1981)

      Specific DDC activity of newly eclosed adult CyO/Ddc heterozygotes, as percentage of CyO/+ control: 52.3

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ddcts2 is rescued by Ddc+t7.5

      (Bishop and Wright, 1987)

      Ddcts2 is rescued by Ddc+t7.5

      (Scholnick et al., 1983)
      Comments

      Cuticle phenotype is rescued by Ddc+t7.5.

      (Bishop and Wright, 1987)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Wright.

      Comments
      Comments

      Induced by ethyl methanesulfonate or formaldehyde.

      (Wright et al., 1981)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ddcts2
      (Silva et al., 2020, Rousseaux et al., 2018, Davis et al., 2008)
      ddcts2
      (Roy et al., 2007)
      l(2)308
      Name Synonyms
      Secondary FlyBase IDs
        References (21)