FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dlg11
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General Information
Symbol
Dmel\dlg11
Species
D. melanogaster
Name
FlyBase ID
FBal0002670
Feature type
allele
Associated gene
Dmel\dlg1
Associated Insertion(s)
Carried in Construct
Also Known As
dlg1, L11
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
ethyl methanesulfonate
(Woods and Bryant, 1989)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  autism spectrum disorder
      CEA with Pak6
      (Grice et al., 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dlg11 mutant embryos show normal cardiac cell alignment.

      (Qian et al., 2005)

      Although discs grow like tumours a large portion of the cells retain properties derived from their epithelial origin: monolayers form in which apical basal polarity is a prominent characteristic, secrete large amounts basement membrane material. Cellular rosette structures are present that have lost the epithelial properties of close contact and polarity.

      (Abbott and Natzle, 1992)

      dlg11/dlg12 lethal at 18oC

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      dlg11, sli2 has dorsal vessel wall cell phenotype

      (Qian et al., 2005)

      dlg1[+]/dlg11, sli2 has dorsal vessel wall cell phenotype

      (Qian et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      sli2/+, dlg11/+ double mutant embryos show defective cardiac cell alignment; a phenotype not observed in either single heterozygote.

      (Qian et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lefevre.

      Comments
      Comments

      Maternal germline clonal analysis demonstrates a maternal effect, poorly differentiated embryos.

      (Perrimon et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      Reported As
      Symbol Synonym
      Dlg1
      (Schimizzi et al., 2016)
      L11
      (Woods and Bryant, 1989, Geer et al., 1983)
      dlg11
      dlg1
      (Bell et al., 2015, Grice et al., 2015, Qian et al., 2005)
      dlgl11
      (Perrimon et al., 1989)
      l(1)L11
      l(1)L11L11
      (Zhimulev et al., 1987)
      l(1)d.lg-1L11
      (Gateff and Mechler, 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (12)