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General Information
Symbol
Dmel\ea2
Species
D. melanogaster
Name
FlyBase ID
FBal0003456
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Point mutation in the catalytic site.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Bacterially challenged ea2/ea7 mutants exhibit a wild type Drs response. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Infection of ea1/ea2 mutants with A.fumigatus causes higher survival rate than wild type, infection with E.coli causes 87% survival 3 days postinfection.

Perivitelline fluid from Tl and dl donors was capable of restoring polarized gastrulation movements and cuticular elements. Perivitelline fluid transplantation using eaD8 embryos as donors and ea1/ea2 embryos as recipients demonstrated that the rescue of the ea phenotype results from the transplantation of the ea gene product.

Ventralized embryos: rings or patches of ventral denticles along dorsoventral axis. Altered pattern of dpp and zen.

Embryos derived from homozygous females are dorsalised.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference

ea2 is a non-suppressor of partially lethal - majority die | recessive phenotype of cact7

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Embryos derived from Spn27Aex32/Df(2L)BSC7 ; ea1/ea2 females are completely dorsalised.

The zygotic semi-lethality of cact7 homozygotes is not suppressed by ea2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (13)