FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ea4
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General Information
Symbol
Dmel\ea4
Species
D. melanogaster
Name
FlyBase ID
FBal0003458
Feature type
allele
Associated gene
Dmel\ea
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos from ea4 mothers develop a dorsalized phenotype resulting from cells at all dorsoventral positions assuming the fate that applies only to dorsal cell types in the wild-type embryo. At gastrulation, these embryos exhibit multiple transverse folds representing extensions of normally dorsal restricted folds and has a cuticle in which shows only dorsally derived structures.

      (Jang et al., 2006)

      Embryos laid by ea4/Df(3R)ea-5022rx1 females are dorsalised.

      (Chang and Morisato, 2002)

      ea4/eaD10 larvae have a wild-type level of muscle defects.

      (Halfon and Keshishian, 1998)

      Mutant embryos respond to injected purified polarizing activity (spz), and produce polarizing activity themselves.

      (Schneider et al., 1994)

      Embryos produced by ea4/Df(3R)ea-5022rx1 females are strongly dorsalised.

      (Schneider et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ventralized phenotype that causes the failure of cuticle differentiation in embryos from Spn27A1/Df(2L)BSC7 mothers is abolished when mothers also have the mutant genotype ea4/Df(3R)ea-5022rx1. Such embryos have a dorsalized phenotype that is indistinguishable from those produced by single mutant ea4/Df(3R)ea-5022rx1 mothers.

      (Hashimoto et al., 2003)

      Perivitelline fluid from embryos laid by eaD1 spz2/ea4 spz4 females shows axis-inducing activity when injected into the the perivitelline space of embryos derived from pip1/pip2 females.

      (Chang and Morisato, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ea4
      (Alpar et al., 2018, Steen et al., 2010, Jang et al., 2006, LeMosy, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (17)