FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\exd2
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General Information
Symbol
Dmel\exd2
Species
D. melanogaster
Name
FlyBase ID
FBal0003911
Feature type
allele
Associated gene
Dmel\exd
Associated Insertion(s)
Carried in Construct
Also Known As
exdYO12, exdY012
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Rauskolb et al., 1995, Peifer and Wieschaus, 1990)

loss of function allele

(Henderson and Andrew, 2000)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C615T.

(Rauskolb et al., 1995)

Amino acid replacement: ?137term.

(Rauskolb et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:15,994,108..15,994,108 [+]
Nucleotide change:

C15994108T

Amino acid change:

Q137term | exd-PA; Q137term | exd-PB; Q137term | exd-PD; Q137term | exd-PE

Reported amino acid change:

?137term

(Rauskolb et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the lateral region of the notum contain several macrochaetae that are not normally present in this region. Large homozygous clones induced using the Minute technique show alterations of the bristle pattern in the scutellum and the disappearance of the suture between the scutum and the scutellum.

      (Aldaz et al., 2005)

      Embryos lack both maternal and zygotic exd.

      (Pinsonneault et al., 1997)

      Most segments are altered in hemizygous embryos. The H piece is often severely disrupted. Ventrally, T1 is normal, T2 is partially transformed to T1, T3 has some of the characteristics of both T1 and A2, Keilin's organs and ventral pits are unchanged, A1-A5 are transformed more posteriorly, assuming the morphology of the segment two or three segments posterior, and A6-A8 are normal or near normal. Anterior and posterior terminal structures are normal.

      (Peifer and Wieschaus, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      exd2/exd[+] is an enhancer of partially lethal - majority die phenotype of Dfd13/Dfd3

      (Florence and McGinnis, 1998)

      exd2 is an enhancer of partially lethal phenotype of Dfd13/Dfd3

      (Pinsonneault et al., 1997)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygotes enhance the lethality of a Dfd3/Dfd13 transheterozygote combination.

      (Pinsonneault et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      E. Wieschaus.

      (Pinsonneault et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      References (15)