FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Klp3A1
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General Information
Symbol
Dmel\Klp3A1
Species
D. melanogaster
Name
FlyBase ID
FBal0004394
Feature type
allele
Associated gene
Dmel\Klp3A
Associated Insertion(s)
Carried in Construct
Also Known As
klp3A521
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Williams et al., 1997)
Progenitor genotype
Cytology
Description

Amino acid replacement: R16C. Nucleotide substitution: C?T.

(Page and Hawley, 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,603,553..2,603,553 [-]
Nucleotide change:

C2603553T

Reported nucleotide change:

C?T

Amino acid change:

R16C | Klp3A-PA; R16C | Klp3A-PB

Reported amino acid change:

R16C

(Page and Hawley, 2005, Williams et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Only 1.90% of eggs derived from Klp3Amei-352/Klp3A1 females hatch. Only 0.34% of eggs derived from Klp3A1/Df(1)ED6579 females hatch. The majority of embryos derived from Klp3Amei-352/Klp3A1 females appear to arrest very early, with only one small nucleus plus a mass of polar body chromatin. The total meiotic exchange frequency for chromosome arm 2L shows little deviation from that of wild-type for Klp3A1/Df(1)ED6579 females, but the distribution of exchanges along the chromosome arm is altered.

      (Page and Hawley, 2005)

      Embryonic defects detectable at preblastoderm stages.

      (Mohler and Carroll, 1984)

      lays eggs. eggs develop. preblastoderm arrest of embryos from mutant mothers.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      12-521
      (Mohler and Carroll, 1984)
      KLP3A521
      (Williams et al., 1997)
      Klp3A1
      Klp3A521
      fs(1)M41
      klp3A521
      (Page and Hawley, 2005, Page et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)