FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Klp3A6
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General Information
Symbol
Dmel\Klp3A6
Species
D. melanogaster
Name
FlyBase ID
FBal0004399
Feature type
allele
Associated gene
Dmel\Klp3A
Associated Insertion(s)
Carried in Construct
Also Known As
klp3A835, 14-835
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Williams et al., 1997, Williams et al., 1995)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Page and Hawley, 2005)

Amino acid replacement: W683term.

(Page and Hawley, 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,601,407..2,601,407 [-]
Nucleotide change:

G2601407A

Reported nucleotide change:

G?A

Amino acid change:

W683term | Klp3A-PA; W683term | Klp3A-PB

Reported amino acid change:

W683term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified).

(Page and Hawley, 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Only 1.46% of eggs derived from Klp3Amei-352/Klp3A6 females hatch. The majority of embryos derived from homozygous or Klp3Amei-352/Klp3A6 females appear to arrest very early, with only one small nucleus plus a mass of polar body chromatin. The total meiotic exchange frequency for chromosome arm 2L shows little deviation from that of wild-type for Klp3A6/Df(1)ED6579 females, but the distribution of exchanges along the chromosome arm is altered.

      (Page and Hawley, 2005)

      Transmission rate of Dp(1;f)J21A through females to progeny is 28%, Klp3A mutation strongly decreases transmission. Mutation also decreases transmission of Dp(1;f)1B, Dp(1;f)25A and Dp(1;f)10B.

      (Cook et al., 1997)

      Heterozygotes with Df(1)63e4 are viable but female sterile (exhibit a maternal effect lethal egg phenotype) and male semi-sterile. Hemizygous males exhibit low fertility, well over half of the males are completely sterile, the remainder exhibit variable fertility.

      (Williams et al., 1995)

      Embryonic defects detectable at preblastoderm stages.

      (Mohler and Carroll, 1984)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Klp3A6 has phenotype, non-suppressible by egh+t7

      (Goode et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Klp3Amei-352

      (Page and Hawley, 2005)
      Rescued by

      Klp3A6 is rescued by Klp3A+tSCA9

      (Williams et al., 1995)
      Comments

      Fertility and cytological phenotypes are rescued by Klp3A+tSCA9.

      (Williams et al., 1995)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      14-835
      (Williams et al., 1995, Mohler and Carroll, 1984)
      KLP3A835
      (Williams et al., 1997, Williams et al., 1995)
      Klp3A6
      fs(1)M46
      klp3A835
      (Page and Hawley, 2005, Cook et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)