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General Information
Symbol
Dmel\Klp3A6
Species
D. melanogaster
Name
FlyBase ID
FBal0004399
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
klp3A835, 14-835
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G2601407A

Reported nucleotide change:

G?A

Amino acid change:

W683term | Klp3A-PA; W683term | Klp3A-PB

Reported amino acid change:

W683term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A.

Amino acid replacement: W683term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Only 1.46% of eggs derived from Klp3Amei-352/Klp3A6 females hatch. The majority of embryos derived from homozygous or Klp3Amei-352/Klp3A6 females appear to arrest very early, with only one small nucleus plus a mass of polar body chromatin. The total meiotic exchange frequency for chromosome arm 2L shows little deviation from that of wild-type for Klp3A6/Df(1)ED6579 females, but the distribution of exchanges along the chromosome arm is altered.

Transmission rate of Dp(1;f)J21A through females to progeny is 28%, Klp3A mutation strongly decreases transmission. Mutation also decreases transmission of Dp(1;f)1B, Dp(1;f)25A and Dp(1;f)10B.

Heterozygotes with Df(1)63e4 are viable but female sterile (exhibit a maternal effect lethal egg phenotype) and male semi-sterile. Hemizygous males exhibit low fertility, well over half of the males are completely sterile, the remainder exhibit variable fertility.

Embryonic defects detectable at preblastoderm stages.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference

Klp3A6 has phenotype, non-suppressible by egh+t7

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Rescued by
Comments

Fertility and cytological phenotypes are rescued by Klp3A+tSCA9.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)