FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gpdh1nGB2
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General Information
Symbol
Dmel\Gpdh1nGB2
Species
D. melanogaster
Name
FlyBase ID
FBal0005149
Feature type
allele
Associated gene
Dmel\Gpdh1
Associated Insertion(s)
P{}Gpdh1nGB2
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Burkhart et al., 1984)
Mutagen
spontaneous
natural population
(Reed and Gibson, 1993, Gibson et al., 1991, Burkhart et al., 1984)
Progenitor genotype
Associated Insertion(s)
P{}Gpdh1nGB2
Cytology
Description

Insertion of defective P element in 5' region of Gpdh gene, at nucleotide position 1305, inserted in the same orientation as the Gpdh gene. Same site of insertion as KP element in GpdhAT198 but this element is smaller due to internal deletion of nucleotides 204-2503.

(Reed and Gibson, 1993)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Less than 50% activity of glycerol-3-phosphate dehydrogenase compared to normal-activity wild type allele.

      (Reed and Gibson, 1993)

      Fast electrophoretic variant.

      (Gibson et al., 1991)

      Same electrophoretic mobility as GpdhB.

      (Burkhart et al., 1984)

      % wildtype enzyme activity: \+ relative enzyme mobility: =GpdhB

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated from: London, England population, September 1977.

      (Burkhart et al., 1984)
      Comments
      Comments

      This variant found in a London, UK, population. See also Gibson et al., 1986, Heredity 56:227--235 , Gibson et al, 1991, Heredity 66:75--82 and Symonds and Gibson, 1992, Biochem. Genet. 30:167--186 .

      (Reed and Gibson, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      GB2
      (Gibson et al., 1991)
      Gpdh1nGB2
      GpdhGB2
      GpdhnGB2
      αGpdhnGB2
      (Burkhart et al., 1984)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0029812
      References (3)