FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gpdh1nSP8
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General Information
Symbol
Dmel\Gpdh1nSP8
Species
D. melanogaster
Name
FlyBase ID
FBal0005188
Feature type
allele
Associated gene
Dmel\Gpdh1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Davis and MacIntyre, 1988)
Mutagen
ethyl methanesulfonate
(Davis and MacIntyre, 1988)
Progenitor genotype
Gpdh1B
Cytology
Description

Nucleotide substitution: T?A.

(Carmon et al., 2010)

Amino acid replacement: Y175term.

(Carmon et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,946,411..5,946,411 [+]
Nucleotide change:

T5946411A

Reported nucleotide change:

T?A

Amino acid change:

Y175term | Gpdh1-PA; Y175term | Gpdh1-PB; Y175term | Gpdh1-PC; Y175term | Gpdh1-PE; Y175term | Gpdh1-PF; Y175term | Gpdh1-PG

Reported amino acid change:

Y175term

(Carmon et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Individuals can fly.

      (Davis and MacIntyre, 1988)

      Adult can fly. Viability is 95% of wild-type.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Relative viability decreases as the genotype approaches the homozygous Gpdh-/Gpo- double null state: phenotype ranges from flightless and viable to lethal. Double null combination with Gpon322 are viable and flightless over the double deletion Df(2L)cl7 Df(2R)WMG chromosome.

      (Davis and MacIntyre, 1988)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Enzyme activity is 9.2% of wild-type. Electrophoretic mobility is less than GpdhB.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Gpdh1nSP8
      GpdhSP8
      (Davis and MacIntyre, 1988)
      GpdhnSP8
      nsp8
      (Carmon et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)