FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\gtQ292
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General Information
Symbol
Dmel\gtQ292
Species
D. melanogaster
Name
FlyBase ID
FBal0005252
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous mutant embryos show a "buttonhead"-type appearance. The terminal larval cuticle shows defects in head involution and ventral denticle patterning. The fifth-through-seventh abdominal denticle belts are missing or fused.

Ectopic thoracic-like hairs are present anterior to the normal rows of first thoracic dorsal hairs in hemizygous mutant embryos.

Hemizygous mutant embryos show fusion of the labial and thoracic segments with labial tissues developing as first thoracic, yielding an enlarged first thoracic segment. The first thoracic denticle belt appears to form at the labial/maxillary border. The anterior denticle row of the first thoracic segment is directly adjacent to the maxillary cirris in some cases. The denticle belt is frequently split at the ventral midline.

Approximately 20% of hemizygous mutant embryos show homeosis of the labial segment to yield two nearly complete first thoracic segments. Labial and thoracic segments do not fuse in these cases, and complete duplication of the first thoracic denticle belt is present in the transformed labial segment.

The dorsal ridge usually remains visible in hemizygous mutant embryos, but is fused in part to the dorsal labial segment.

Muscle pattern wild type within constraints imposed by alterations in body plan. Muscles contractile and vigorous.

gtQ292/gtE6 larvae synthesise DNA of a reduced molecular weight, have an unusually high frequency of spontaneous single and double-strand breaks, and shows a reduction in the normal inhibition of DNA synthesis following treatment with UV. gtQ292/gt1 larvae show a reduction in the normal inhibition of DNA synthesis following treatment with N-acetoxy-2-acetylaminofluorene.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Embryos hemizygous for gtQ292 and homozygous for tsh8 show normal lobe-like morphology of the labial segment. The dorsal ridge is enlarged, but is separate from the labial segment in late-stage mutant embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Shen.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)