FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\haync2rv2
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General Information
Symbol
Dmel\haync2rv2
Species
D. melanogaster
Name
FlyBase ID
FBal0005386
Feature type
allele
Associated gene
Dmel\hay
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Regan and Fuller, 1990)
Mutagen
ethyl methanesulfonate
(Regan and Fuller, 1990)
Progenitor genotype
haync2
(Mounkes and Fuller, 1999, Regan and Fuller, 1990)
Cytology
Description

Amino acid replacement: C377Y. C377 lies 8 amino acids downstream of the P loop in the nucleotide-binding domain. Nucleotide substitution: G?A.

(Mounkes and Fuller, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:10,632,579..10,632,579 [+]
Nucleotide change:

G10632579A

Reported nucleotide change:

G?A

Amino acid change:

C371Y | hay-PA; C371Y | hay-PB

Reported amino acid change:

C377Y

Comment:

The amino acid numbering differs between FBrf0108244 and the reference sequence. The positions and nature of the base substitutions in the mutants are derived from the sequence in Fig. 1 and from Table 1, and provide unambiguous assignments.

(Mounkes and Fuller, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      haync2/haync2rv2 animals show 45.6% viability. 49.1% of haync2/haync2rv2 adults have deformed and fragile macrochaetae and microchaetae, 12.0% have a reduction of the endocuticular layer of the abdominal cuticle and 9.6% show loss of wing marginal regions and blistered wings.

      (Merino et al., 2002)

      Lethal over deficiency of hay. Heterozygotes exhibit defects in the structure and function of the male meiotic spindle.

      (Regan and Fuller, 1990)

      recessive larval lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Cdk7P140S, hay[+]/haync2rv2 has visible phenotype

      (Merino et al., 2002)

      Cdk7P140S, haync2rv2 has visible phenotype

      (Merino et al., 2002)
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies carrying Cdk7P140S in a heterozygous Df(1)JB254 P{snf+,dhd+} background (the Df(1)JB254 chromosome is deficient for Cdk7, snf and dhd and snf and dhd function is provided by the P{snf+,dhd+} transgene) at the restrictive temperature that are also carrying one copy of haync2rv2 show brittle bristle and cuticle defect phenotypes.

      (Merino et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      haync2rv2
      Name Synonyms
      Secondary FlyBase IDs
        References (3)