FlyBase Allele Report: Dmel\l(1)16Fe[1]

General Information

Symbol

Dmel\l(1)16Fe¹

Species

D. melanogaster

Name

FlyBase ID

FBal0006232

Feature type

allele

Associated gene

l(1)16Fe

Associated Insertion(s)

Carried in Construct

Also Known As

1614

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(de la Pompa, 1994)

Mutagen

ethyl methanesulfonate

(Prado et al., 1999, de la Pompa, 1994, Barbas et al., 1991, Ferrus et al., 1990)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Ferrus et al., 1990)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology

(Barbas et al., 1991, Ferrus et al., 1990)

lethal

(Barbas et al., 1991)

lethal | recessive

(Prado et al., 1999, de la Pompa, 1994, Ferrus et al., 1990)

Phenotype Manifest In

adult somatic muscle cell

(Prado et al., 1999)

leg

(Ferrus et al., 1990)

wing

(Ferrus et al., 1990)

Detailed Description

Statement

Reference

l(1)16Fe¹ shows a distributed lethal phase along development. Occasionally, homozygous pharate adults with severe muscle defects are seen.

(Prado et al., 1999)

Causes wupA^hdp-2 mutant phenotype to become more extreme. Heterozygous females have a hyperplasic and poorly structured tergal depressor of the trochanter muscle (TDT) and they shake their appendages (CGF action potentials are abnormal).

(Barbas et al., 1991)

Gynandromorph analysis demonstrates the mutation is lethal. Surviving adults have normal bristles but abnormal positions of wings and legs. Visible shaking activity: abnormal CGF action potentials. Homozygous ovarioles from germline mosaics give rise to mutant survivors. Heterozygotes have a visible shaking activity, CGF action potentials have an abnormal profile.

(Ferrus et al., 1990)

Major lethal phase in second larval instar. Somatic mosaics in the adult hypoderm show normal cuticle. Gynandromorphs exhibit vibrating appendages and abnormal wing position in the mutant side. Germ-line clones normal.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

l(1)16Fe¹, wupA^hdp-3 has visible | dominant phenotype

(Prado et al., 1999)

l(1)16Fe¹, wupA^hdp-3 has abnormal flight | dominant phenotype

(Prado et al., 1999)

l(1)16Fe¹, wupA^hdp-2 has visible | dominant phenotype

(Prado et al., 1999)

l(1)16Fe¹, wupA^hdp-2 has abnormal flight | dominant phenotype

(Prado et al., 1999)

Phenotype Manifest In

Other

Statement

Reference

l(1)16Fe¹, wupA^hdp-3 has wing phenotype

(Prado et al., 1999)

l(1)16Fe¹, wupA^hdp-3 has adult somatic muscle cell phenotype

(Prado et al., 1999)

l(1)16Fe¹, wupA^hdp-2 has wing phenotype

(Prado et al., 1999)

l(1)16Fe¹, wupA^hdp-2 has adult somatic muscle cell phenotype

(Prado et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Fails to complement wupA^hdp-2 or wupA^hdp-3 with respect to wing position, flight and jump behaviour and muscle structure. Fails to complement the semi-dominant lethality of wupA⁸³⁸⁴ or wupA²⁴⁵⁹⁷.

(Prado et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutation in the haplo-lethal (HL) region of the Sh complex.

(Ferrus et al., 1990)

Mutation within the haplo-lethal (HL) region of the Sh complex.

(de la Pompa, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

1614

(Ferrus, 1999.3.4, Prado et al., 1999, Barbas et al., 1991)

l(1)1614

(de la Pompa, 1994)

l(1)16Fe¹

wupA^16Fe-1

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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