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General Information
Symbol
Dmel\Rca103300
Species
D. melanogaster
Name
FlyBase ID
FBal0008022
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
rca1P1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{PZ} insertion 42bp upstream of the start codon.

Insertion components
P{PZ}Rca103300
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

86% of mutant embryos lack eve expressing pericardial cells (EPC), the rest show one EPC per hemisegment (instead of the two seen in wild-type). DA1 muscles form as in wild-type. A halving is also seen in the number of myocardial cells seen in segments A2 to A7, though the number seen in segments T3 to A1 remain normal.

In mutant embryos, the ganglion mother cells, GMC1-1a and GMC4-2a fail to divide into their normal progeny. The non-dividing GMC1-1a and GMC4-2a cells are larger than normal and sit where its offspring should normally be. A loss of approximately 10% of EL neurons is also seen.

In mutant embryos the division of neurons are affected in a lineage specific manner. The ganglion mother cell (GMC) of the RP2/sib lineage fails to divide, and assumes the identity of the RP2 neuron. The GMC of the aCC/pCC lineage is similarly affected; it fails to divide and assumes the identity of the aCC. These phenotypes are fully penetrant. Timing and axonal projections from these neurons continue as if they were wildtype. Other lineages are also affected in mutant embryos. The CQ lineage fails to divide in about 50% of hemisegments and the U lineage fails to divide in 65% of hemisegments. The effect on the EL line is minimal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Dominantly enhances the rough eye phenotype of CycEJP homozygotes. One copy of Rca103300 has no effect on the reduction in the number of cells entering S phase posterior to the morphogenetic furrow seen in CycEJP homozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Complements: Hrb27C02647. Complements: smt304841. Complements: mam07221. Complements: Hrb27C10280. Complements: smt310636. Complements: xl6k00230. Complements: nrv2k04223. Complements: smt3k06307. Complements: l(2)k09022k09022. Complements: Coproxk10617. Complements: nrv2k13315. Complements: poe03420.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (10)