FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sm05338
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General Information
Symbol
Dmel\sm05338
Species
D. melanogaster
Name
FlyBase ID
FBal0008085
Feature type
allele
Associated gene
Dmel\sm
Associated Insertion(s)
P{PZ}sm05338
Carried in Construct
Also Known As
sm4
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(zur Lage et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{PZ}sm05338
Cytology
Description

Insertion of a P{PZ} element in the first exon, at position 270 +/- 3 of the exon. This insertion is in the 5' untranslated region.

(zur Lage et al., 1997)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Chemosensory and mechanosensory bristles are present in normal numbers and patterns and have a normal morphology on the wing and leg in mutant flies. Mutant flies show loss of abdominal sternite bristles.

      Homozygous adults do not survive for more than 2-4 days. Mutant flies do not accumulate food coloration in the crop after 16 hours on colored food, suggesting that they do not feed properly.

      Chemosensory axons in the legs of mutant flies can have abnormal projections with a reduced arborisation (4 out of 8 cases) and in other cases (3 out of 8 cases) the projection pattern appears more similar to that seen for wild-type mechanosensory neurons than for wild-type chemosensory neurons (both with respect to the projection path and the extent and depth of the terminal arbor). The dendrites of the chemosensory neurons in the leg do not show any defects.

      (Layalle et al., 2005)

      The homozygous phenotype is similar to that of sm3 homozygotes.

      (zur Lage et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      sm[+]/sm05338 is an enhancer of visible | dominant phenotype of N55e11

      (Kankel et al., 2007)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      sm[+]/sm05338 is an enhancer of wing phenotype of N55e11

      (Kankel et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly enhances the Df(1)N-54l9/+ and N55e11/+ wing nicking phenotypes.

      (Kankel et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Df(2R)BSC820 failed to complement sm[05338] for female sterility.

      (Christensen et al., 2009.6.15)

      Shown by complementation to be allelic to sm2.

      (zur Lage et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: 18w00053. Complements: hts00634. Complements: hts01103. Complements: emm1.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      l(2)05338
      (Spradling et al., 1999)
      l(2)0533805338
      sm05338
      (Draper et al., 2024)
      sm05338
      (Christensen et al., 2009.6.15, Christensen et al., 2009.7.22, Kankel et al., 2007)
      sm4
      (Layalle et al., 2005, zur Lage et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)