FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gek09373
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General Information
Symbol
Dmel\gek09373
Species
D. melanogaster
Name
FlyBase ID
FBal0008145
Feature type
allele
Associated gene
Dmel\gek
Associated Insertion(s)
P{PZ}gek09373
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Luo et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{PZ}gek09373
Caused by aberration
Df(2R)09373
Cytology
Description

The sequence flanking the 3' end of the P{PZ} insertion in the "l(2)09373" line maps to the 5' end of the gek gene. The sequence flanking the 5' end of the P{PZ} insertion in the "l(2)09373" line maps approximately 16kb upstream, to a site between the divergently transcribed genes CG4049 and CG3253. This suggests that the "l(2)09373" line either contains one P{PZ} insertion which is associated with a deletion of approximately 16kb, or two P{PZ} insertions which map approximately 16kb apart (Luo, 2001.9.24, personal communication to FlyBase indicates that the chromosome has a deletion rather than two P{PZ} insertions).

(Levis, 2001.7.6)

P{PZ} insertion at the 5' end of gek (P{PZ}gek09373) together with a deletion (Df(2R)09373).

(Luo, 2001.9.24)

P-element insertion in the 5' untranslated region of the gek transcription unit between nucleotides 51 and 52. Chromosome also carried deletion of sequences upstream of the insertion site.

(Luo et al., 1997)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Germline clones produce normal eggs, 84% have no cuticle development and others have variable defects. Lethality occurs during the embryonic and larval stages.

      (Perrimon et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Reversion analysis proved that the P{PZ} is responsible for the lethal phenotype.

      (Beaton, 2000.1.31)

      It is not known whether the lethality of the "l(2)09373" line is associated with the insertion/breakpoint in gek, or sequences removed by the deletion Df(2R)09373.

      (Levis, 2001.7.6)

      Complements: tsr00026. Complements: eIF-5A01296. Complements: l(2)0500605006. Complements: eIF-5A10530. Complements: l(2)rQ313rQ313.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      MdaPk09373
      (Beaton, 2000.1.31)
      gek09373
      (Rudrapatna et al., 2014)
      gekP
      l(2)09373
      (Levis, 2001.7.6, Luo, 2001.9.24, Spradling et al., 1999)
      l(2)0937309373
      (Perrimon et al., 1996, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0085824
      References (11)