FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CIAPIN12
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General Information
Symbol
Dmel\CIAPIN12
Species
D. melanogaster
Name
FlyBase ID
FBal0008502
Feature type
allele
Associated gene
Dmel\CIAPIN1
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)br26OK5
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, O'Donnell et al., 1977)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Gubb et al., 1984)
Description

Amino acid replacement: C212Y.

(Marzuk et al., 2013)

Nucleotide substitution: G635A.

(Marzuk et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:15,037,984..15,037,984 [-]
Nucleotide change:

G15037984A

Amino acid change:

C212Y | CIAPIN1-PA

Reported amino acid change:

C212Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Marzuk et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CIAPIN12/CIAPIN1NP5152 females have rudimentary ovaries, which contain no egg chambers beyond stage 8 of development. A loss of follicle cells is seen, such that follicle cell tissue fails to cover the entire egg chamber. A significant reduction in the number of follicle cells per egg chamber is seen by stage 4. An increased level of follicle cell apoptosis is seen compared to wild type, with apoptosis being detected as early as stage 2. Follicle cell replication (as assayed by BrdU incorporation) appear normal, but there is a marked decrease in mitotic index of the follicle cells compared to wild type, with more than 90% of stage 2-4 egg chambers having a mitotic index of zero. All phases of mitosis are readily identified in the mutant follicle cells, with no significant difference in the fraction of cells in each phase compared to wild type.

      (Marzuk et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      CIAPIN1k10011

      (Roote, 1998.11.16)
      Rescued by

      CIAPIN12/CIAPIN1NP5152 is rescued by Scer\GAL4Act.PU/CIAPIN1UASp.cMa

      (Marzuk et al., 2013)

      CIAPIN12 is rescued by Scer\GAL4Act.PU/CIAPIN1UASp.cMa

      (Marzuk et al., 2013)
      Not rescued by

      CIAPIN12/CIAPIN1NP5152 is not rescued by Scer\GAL4VP16.nanos.UTR/CIAPIN1UASp.cMa

      (Marzuk et al., 2013)
      Comments

      Expression of CIAPIN1Scer\UAS.P\T.cMa under the control of Scer\GAL4Act.PU rescues the lethality of CIAPIN12 homozygotes, and rescues the sterility of CIAPIN12/CIAPIN1NP5152 males and females.

      Expression of CIAPIN1Scer\UAS.P\T.cMa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 fails to rescue ovarian development in CIAPIN12/CIAPIN1NP5152 females.

      (Marzuk et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      O'Donnell.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      CIAPIN12
      (Marzuk et al., 2013)
      OK-5
      (O'Donnell et al., 1977)
      OK5
      l(2)35Bg2
      (Marzuk et al., 2013, Christensen and Cook, 2007.5.8)
      l(2)35BgOK5
      (Roote, 1998.11.16)
      l(2)br26OK5
      (Gubb et al., 1984, Ashburner, 1982)
      ok5
      (Furukawa et al., 1992)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)