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General Information
Symbol
Dmel\Lim36
Species
D. melanogaster
Name
FlyBase ID
FBal0008653
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Lim3BD6, Bd6
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

A 9bp deletion in the 3 UTR which may affect mRNA stability.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

9bp deletion (bases 1,698-1706) in the 3' untranslated region which may affect the stability of the mRNA.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In Lim36/+ embryos less than 1% of muscles 12 and 13 fail to be innervated and less than 3% of ISNb axons leave the ventral muscle field and target the transverse nerve (TN) fascicle. In stage 16 Lim36/Df(2L)TW130 embryos, 19% of hemisegments have no transverse nerve, while 38% of hemisegments have transverse nerve fasciculation defects.

Most hemizygotes do not pupariate, remaining as second or third instar larvae up to 8 or 9 days after egg laying. A few hemizygotes do pupariate 8 to 11 days after egg laying, and these pupae generally develop into pharate adults that do not eclose. These pharate adults show a complete lack of differentiated cuticle on the abdomen, and have reduced cuticle formation on the thorax and head.

Hemizygous Lim36/Df(2L)TW130 animals do not survive to the third larval instar stage.

strong allele in which second and third instar larvae persist until days eight and nine; few survive to pharate-adult stage with incomplete sclerotization.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Lim36, vvl[+]/vvldfr-B129 has abnormal neuroanatomy | dominant phenotype, enhanceable by tupisl-1/tup[+]

Lim3[+]/Lim36, vvldfr-B129 has abnormal neuroanatomy | dominant phenotype, enhanceable by tupisl-1/tup[+]

Lim36 has abnormal neuroanatomy | dominant phenotype, enhanceable by vvl[+]/vvldfr-B129

Enhancer of
Statement
Reference

Lim3[+]/Lim36 is an enhancer of abnormal neuroanatomy | dominant phenotype of vvldfr-B129

Lim3[+]/Lim36 is an enhancer of abnormal neuroanatomy | dominant phenotype of tupisl-1, vvl[+]/vvldfr-B129

Lim3[+]/Lim36 is an enhancer of abnormal neuroanatomy | dominant phenotype of tupisl-1/tup[+], vvldfr-B129

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

In Lim36/+ embryos less than 1% of muscles 12 and 13 fail to be innervated and less than 3% of ISNb axons leave the ventral muscle field and target the transverse nerve (TN) fascicle. The expressivity of these phenotypes is enhanced to 29% and 34% respectively by vvldfr-B129/+. In tupisl-1, Lim36/+; vvldfr-B129/+ embryos, the ISNb motoneurons fail to project to and innervate their specific target muscles, including muscles 12 and 13. In stage 16 Lim36/+ Df(2L)TE35D-19/+ embryos, 17% of hemisegments have no transverse nerve, while 25.5% of hemisegments have transverse nerve fasciculation defects. In stage 16 tup1/+ Lim36/+ Df(2L)TE35D-19/+ embryos, 9.3% of hemisegments have no transverse nerve, while 36% of hemisegments have transverse nerve fasciculation defects. In stage 16 tup1/+ Lim36/+ Df(2L)TE35D-19/+ embryos, 4% of hemisegments have no transverse nerve, while 46% of hemisegments have transverse nerve fasciculation defects.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Wright.

Comments
Comments

Strong allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)