FlyBase Allele Report: Dmel\Cap-G[49Ff-6]

General Information

Symbol

Dmel\Cap-G^49Ff-6

Species

D. melanogaster

Name

FlyBase ID

FBal0009072

Feature type

allele

Associated gene

Dmel\Cap-G

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lasko and Pardue, 1988)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q77term.

(Jager et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:13,133,542..13,133,542 [+]

Nucleotide change:

C13133542T

Amino acid change:

Q77term | Cap-G-PF; Q77term | Cap-G-PG

Reported amino acid change:

Q77term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Jager et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle

(Jager et al., 2005)

abnormal mitotic cell cycle (with Cap-G^49Ff-3)

(Jager et al., 2005)

lethal (with Cap-G^EP2346)

(Jager et al., 2005)

lethal | recessive

(Renn et al., 1998, Lasko and Pardue, 1988)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous embryos analysed at a stage when epidermal cells are progressing through mitosis 15 have massive anaphase defects. Anaphase figures contain bridges and often a large part of the chromatin mass appear to reside within the cleavage plane.

Cap-G^49Ff-3/Cap-G^49Ff-6 embryos analysed at a stage when epidermal cells are progressing through mitosis 15 have massive anaphase defects, although metaphase morphology appears normal.

(Jager et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

l(2)49Ff[+]/Cap-G^49Ff-6 is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, cid^UAS.cJa

(Jager et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

l(2)49Ff[+]/Cap-G^49Ff-6 is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, cid^UAS.cJa

(Jager et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cap-G^49Ff-1/Cap-G^49Ff-6 is rescued by Cap-G^UAS.FL.EGFP/Scer\GAL4^da.G32

(Herzog et al., 2013)

Cap-G^49Ff-1/Cap-G^49Ff-6 is rescued by Scer\GAL4^da.G32/Cap-G^NM.UAS.EGFP

(Herzog et al., 2013)

Cap-G^49Ff-1/Cap-G^49Ff-6 is rescued by Cap-G^NM.UASp.EGFP/Scer\GAL4^da.G32

(Herzog et al., 2013)

Partially rescued by

Cap-G^49Ff-3/Cap-G^49Ff-6 is partially rescued by Cap-G^t11.2

(Jager et al., 2005)

Cap-G^49Ff-1/Cap-G^49Ff-6 is partially rescued by Cap-G^UASp.cJa/Scer\GAL4^da.G32

(Jager et al., 2005)

Comments

Expression of Cap-G^{NM.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^da.G32 rescues the lethality of Cap-G^49Ff-1/Cap-G^49Ff-6 animals, with adult flies being obtained with high efficiency.

Expression of Cap-G^{NM.Scer\UAS.P\T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^da.G32 rescues the lethality of Cap-G^49Ff-1/Cap-G^49Ff-6 animals and fertility is restored in both sexes.

(Herzog et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Lasko.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Cap-G^49Ff-6

Cap-G⁶

(Herzog et al., 2013)

l(2)43

l(2)49Ff⁶

(Jager et al., 2005)

vr9,15-43

(Renn et al., 1998)

vr9⁴³

(Wu and Howe, 1995)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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