FB2026_02 , released June 18, 2026
Allele: Dmel\eIF3e10547
Open Close
General Information
Symbol
Dmel\eIF3e10547
Species
D. melanogaster
Name
FlyBase ID
FBal0009625
Feature type
allele
Associated gene
Dmel\eIF3e
Associated Insertion(s)
P{PZ}eIF3e10547
Carried in Construct
Also Known As
l(3)10547
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Cunniff et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{PZ}eIF3e10547
Cytology
Description

Insertion in the second exon, 204bp downstream of the first ATG codon.

(Rencus-Lazar et al., 2008)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  autosomal dominant cerebellar ataxia
      modeled by Hsap\ATXN8OSCTG112.UAS
      (Mutsuddi et al., 2004)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae are small compared to their heterozygous siblings and die within 2-4 days after hatching while still at the first instar stage (their heterozygous siblings have progressed to the third instar stage by this time).

      Homozygous clones in the wing and eye discs are much smaller than their adjacent control twin spots, and the clones appear to be eliminated by the adult stage.

      Homozygous female germ-line clones arrest at stage 5-6 of oogenesis.

      (Rencus-Lazar et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Int6[+]/eIF3e10547 is a suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF

      (Mutsuddi et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      eIF3ej9E8

      (BDGP Project Members, 1994-1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      After six generations of outcrossing the lethality continued to segragate with the P{PZ} insertion.

      (Beaton, 2000.1.31)

      Precise excision of the insertion reverts the lethal phenotype.

      (Rencus-Lazar et al., 2008)

      Complements: l(3)04069b04069b. Complements: tapj2B12. Complements: Baldspotneo22. Complements: l(3)s1629bs1629b. Complements: l(3)s1629bs1664.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Int610547
      eIF3e10547
      l(3)10547
      (Mutsuddi et al., 2004, Spradling et al., 1999, Cunniff et al., 1997)
      l(3)1054710547
      (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)