FB2026_02 , released June 18, 2026
Allele: Dmel\Vha559
Open Close
General Information
Symbol
Dmel\Vha559
Species
D. melanogaster
Name
FlyBase ID
FBal0010423
Feature type
allele
Associated gene
Dmel\Vha55
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)SzA9
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Davies et al., 1996, Gausz et al., 1979)
Progenitor genotype
Cytology
Description

Also carries a GTC to GTG nucleotide change (silent mutation at a Val residue).

(Du et al., 2006)

Amino acid replacement: G?V.

(Du et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:12,625,807..12,625,807 [-]
Nucleotide change:

G12625807T

Reported nucleotide change:

G?T

Amino acid change:

G165V | Vha55-PA; G165V | Vha55-PB; G165V | Vha55-PC

Reported amino acid change:

G?V

Comment:

Reported as a missense mutation in the second coding exon of Vha55 in the Gly of the string ARGQK from GGC to GTC. Also carries a silent GTC to GTG nucleotide change at another Val codon in the same exon.

(Du et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Vha559 homozygous flies expressing Vha55Scer\UAS.T:Avic\GFP under the control of Scer\GAL4hs.PU (rescue flies) are viable and their Malphigian tubules show normal resting secretion rates but reduced maximum stimulation fluid secretion.

      (Du et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Vha559 is rescued by Vha55UAS.GFP/Scer\GAL4hs.PU

      (Du et al., 2006)
      Comments

      The lethality of Vha559 homozygous mutants is rescued by expression of Vha55Scer\UAS.T:Avic\GFP under the control of Scer\GAL4hs.PU in the mutant background.

      (Du et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      SzA9
      (Davies et al., 1996)
      Vha559
      l(3)SzA9
      (Du et al., 2006, Allan et al., 2005, Gausz et al., 1979)
      vha55SzA9
      (Du et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)