FB2026_03 , released September 17, 2026
Allele: Dmel\l(3)hem1
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General Information
Symbol
Dmel\l(3)hem1
Species
D. melanogaster
Name
FlyBase ID
FBal0010873
Feature type
allele
Associated gene
l(3)hem
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Lacks blood cells in hematopoietic organs and lacks plasmatocytes and crystal cells in blood. Polytene chromosomes in nuclei of optic lobe neuroblasts.

        (Gateff, 1994)

        Cytokinesis in primordial larval blood cells and adult optic neuroblasts in the embryonic larval brain fails.

        (Gateff and Schmidt, 1991)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        l(3)hem1/l(3)hem1 is a suppressor | partially of melanotic mass phenotype phenotype of Dp(3;3)Karel

        (Dolezal et al., 2005)
        NOT Suppressor of
        Statement
        Reference

        l(3)hem1/l(3)hem1 is a non-suppressor of abnormal developmental rate phenotype of Dp(3;3)Karel

        (Dolezal et al., 2005)
        Phenotype Manifest In
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        l(3)hem1/l(3)hem1 is a non-suppressor of pupal abdomen phenotype of Dp(3;3)Karel

        (Dolezal et al., 2005)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        l(3)hem1 suppresses some of the Dp(3;3)Karel mutant phenotypes; the number of circulating hemocytes in late third instar l(3)hem1 Dp(3;3)Karel double mutant larvae is significantly reduced compared to Dp(3;3)Karel single mutant larvae. In addition, only 40% of the double mutant larvae show disintegration of the fat body compared to 90% of Dp(3;3)Karel single mutants, and only 55% of the double mutant larvae have melanotic tumours compared to more than 83% of Dp(3;3)Karel single mutants. The delay in development, block in pupariation and abnormal shape of Dp(3;3)Karel pupae are not suppressed by l(3)hem1.

        (Dolezal et al., 2005)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        DNA synthesis is not inhibited within primordial larval blood cells, in the adult optic neuroblasts many rounds of DNA synthesis occur without cytokinesis.

        (Gateff and Schmidt, 1991)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        l(3)hem1
        Name Synonyms
        Secondary FlyBase IDs
          References (4)