FlyBase Allele Report: Dmel\Diap1[j5C8]

(Verghese et al., 2012, Cooper and Kennison, 2011, Chen et al., 2008, Huang et al., 2005, Lai et al., 2005, Geisbrecht and Montell, 2004, Wu et al., 2003, Spradling et al., 1999, Braun et al., 1997, Hay et al., 1995, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

exacerbates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN7^{102Q.T.UAS.Tag:NLS(SV40-largeT)}

(Latouche et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, Hay et al., 1995)

Phenotype Manifest In

border follicle cell | somatic clone

(Geisbrecht and Montell, 2004)

follicle cell | somatic clone

(Geisbrecht and Montell, 2004)

Detailed Description

Statement

Reference

Homozygous follicle cells clones result in border follicle cell migration defects. In large homozygous clones in the follicle epithelium, multinucleate cells are seen. Mutant outer follicle cell clones do not show TUNEL labeling, even 10 days after clone induction.

(Geisbrecht and Montell, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Diap1^j5C8 is an enhancer of short lived | RU486 conditional phenotype of Hsap\ATXN7^{102Q.T.UAS.Tag:NLS(SV40-largeT)}, Scer\GAL4^{elav.Switch.PO}

(Latouche et al., 2007)

Diap1^j5C8 is an enhancer of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Morris et al., 2006)

Diap1^j5C8 is an enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

Diap1^j5C8 is an enhancer of wing blade phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Morris et al., 2006)

Diap1^j5C8 is an enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Diap1^j5C8 is an enhancer of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by th^j5C8.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

12093

y¹ w^*; P{lacW}Diap1^j5C8/TM3, Sb¹

Kyoto

111396

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}Diap1^j5C8 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹

Notes on Origin

Discoverer

L. and Y. Jan.

Comments

The P{lacW}th^j5C8 insertion is in the same position as the P{EP}th^EP3308 insertion.

(Geisbrecht and Montell, 2004)

Complements: Mbs^j3B4. Complements: Mbs^j7A1.

(BDGP Project Members, 1994-1999)

Transposase induced excision of the P{lacW} is accompanied by reversion of the mutant phenotype.

(Hay et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Diap1^j5C8

(Skouloudaki et al., 2019, Yee et al., 2019)

Th^j5C8

(Latouche et al., 2007)

l(3)j5C8

(Geisbrecht and Montell, 2004, Spradling et al., 1999, Hay et al., 1995)

l(3)j5C8^j5C8

th^J5C8

(McSharry and Beitel, 2019)

th^j5C8

th^j5c8

(Bunker et al., 2015, Wang et al., 2008, Guan et al., 2007, Wu et al., 2003)

th^jc58

(Bennett and Harvey, 2006)

th^l(3)j5C8

(Morris et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (24)

Report Sections

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