FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Med5
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General Information
Symbol
Dmel\Med5
Species
D. melanogaster
Name
FlyBase ID
FBal0011207
Feature type
allele
Associated gene
Dmel\Med
Associated Insertion(s)
Carried in Construct
Also Known As
medea5
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The average number of crystal cells per embryo is significantly reduced in homozygous stage 13-14 embryos compared to wild type.

      (Milchanowski et al., 2004)

      Lethality occurs during larval and pupal stages.

      (Raftery, 1995.4.6)

      Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells and affects chromosome condensation.

      (Gatti and Baker, 1989)

      imaginal discs missing weak effect on mitotic chromosome condensation; low mitotic index

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Med5 is a suppressor of abnormal neuroanatomy phenotype of spictmut

      (Wang et al., 2007)

      Med[+]/Med5 is a suppressor | partially of abnormal neuroanatomy phenotype of spictmut

      (Wang et al., 2007)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Med[+]/Med5 is a suppressor | partially of embryonic/larval neuromuscular junction phenotype of spictmut

      (Wang et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      spictmut neuromuscular junction overgrowth phenotypes are fully suppressed in Med5/Med5 mutants. The synaptic undergrowth phenotypes in larvae homozygous for spictmut in a Med5/Med5 background are indistinguishable from that of Med5/Med5 mutants alone. In addition, a heterozygous Med5 background partially suppresses the neuromuscular junction expansion of spictmut larvae.

      (Wang et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Med13

      (Cook, 2006.1.31)

      Med1

      (Cook, 2006.1.31)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      l(3)SG36 was previously mis-mapped.

      (Raftery, 1995.4.6)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      11m254
      Med5
      l(3)SG361
      med5
      (Kang et al., 2014)
      medea5
      (Wartlick et al., 2011)
      Name Synonyms
      medea5
      (Wang et al., 2007)
      Secondary FlyBase IDs
        References (8)