FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\M(SD)1
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General Information
Symbol
Dmel\M(SD)1
Species
D. melanogaster
Name
FlyBase ID
FBal0011971
Feature type
allele
Associated gene
M(SD)
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      RanGAPβTub85D.PK causes very strong segregation distortion in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. Segregation distortion does not occur if the target homolog chromosome carries Rspi in place of Rspss. Overexpression of RanGAPβTub85D.PK does not cause segregation distortion in the presence of the "SD-5[R16]" chromosome (which carries a strong suppressor of SD in addition to RanGAPSd, E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. Segregation distortion can occur in the absence of RanGAPSd if flies are homozygous for E(SD)1 : Flies carrying chromosome SD-5[R7] (E(SD)1, Rspi M(SD)1 St(SD)1) / chromosome ReR-5 (E(SD)1 Rsps) exhibit moderate segregation distortion (k=0.74 +/-0.014) against ReR-5. This can be suppressed by the presence of RanβTub85D.PK or Rcc1βTub85D.PK. RanβTub85D.PK and Rcc1βTub85D.PK can both suppress the segregation distortion phenotype caused by RanGAPβTub85D.PK in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss.

      (Kusano et al., 2002)

      Segregation distortion is not seen RanGAPSd.tPa.1 flies in the presence of E(SD)1 or of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1). RanGAPSd.tPa induces high levels of segregation distortion in the presence of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss or Rsps.

      (McLean et al., 1994)

      M(Sd)1 enhances the activity of RanGapSD in an RanGapSD Rspss/RanGap+ Rspss male, and both homologues are distorted (rendered dysfunctional) in very high frequencies. Approximately 60-70% of the males are completely sterile.

      (Hiraizumi et al., 1980)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (6)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Not the same as E(Sd).

      M(Sd) is held in linkage disequilibrium with RanGapSD by inversions in many native SD chromosomes.

      (Temin, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      M(SD)
      (Hiraizumi et al., 1980)
      M(SD)1
      M(Sd)1
      Name Synonyms
      Secondary FlyBase IDs
        References (5)