FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rspi
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General Information
Symbol
Dmel\Rspi
Species
D. melanogaster
Name
insensitive
FlyBase ID
FBal0014786
Feature type
allele
Associated gene
Rsp
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
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        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        insensitive

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        RanGAPβTub85D.PK causes very strong segregation distortion in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. Segregation distortion does not occur if the target homolog chromosome carries Rspi in place of Rspss. Overexpression of RanGAPβTub85D.PK does not cause segregation distortion in the presence of the "SD-5[R16]" chromosome (which carries a strong suppressor of SD in addition to RanGAPSd, E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. Segregation distortion can occur in the absence of RanGAPSd if flies are homozygous for E(SD)1 : Flies carrying chromosome SD-5[R7] (E(SD)1, Rspi M(SD)1 St(SD)1) / chromosome ReR-5 (E(SD)1 Rsps) exhibit moderate segregation distortion (k=0.74 +/-0.014) against ReR-5. This can be suppressed by the presence of RanβTub85D.PK or Rcc1βTub85D.PK. RanβTub85D.PK and Rcc1βTub85D.PK can both suppress the segregation distortion phenotype caused by RanGAPβTub85D.PK in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss.

        (Kusano et al., 2002)

        Segregation distortion is not seen in RanGAPSd.tPa.1 flies in the presence of E(SD)1 or of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1). RanGAPSd.tPa induces high levels of segregation distortion in the presence of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss or Rsps.

        (McLean et al., 1994)

        Under certain genotypic conditions, the chromosome carrying the "sensitive" Rsps allele in a RanGapSD heterozygous Rspi/Rsps male can be transmitted to the progeny at frequencies greater than 0.5, or correspondingly, the chromosome carrying the "insensitive" Rspi allele can be distorted with respect to the chromosome carrying the "sensitive" Rsps allele. This "negative segregation distortion" indicates that the relative sensitivity and insensitivity of Rsps and Rspi to distortion in a male are not absolute, but relative, and they may be reversed depending on the residual genotype.

        (Hiraizumi, 1989)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (4)
        Notes on Origin
        Discoverer
        Comments
        Comments

        All Rspi chromosomes lack the h39 region.

        (Pimpinelli and Dimitri, 1989)

        The insensitive state of Rsp.

        (Temin, 1991)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        Rsp
        Rspi
        (Gell and Reenan, 2013)
        Rspins
        Name Synonyms
        insensitive
        (Temin, 1991)
        Secondary FlyBase IDs
          References (20)