FlyBase Allele Report: Dmel\mei-41[D18]

General Information

Symbol

Dmel\mei-41^D18

Species

D. melanogaster

Name

FlyBase ID

FBal0012169

Feature type

allele

Associated gene

Dmel\mei-41

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Mohler, 1977)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

egg | maternal effect

(Mohler, 1977)

Detailed Description

Statement

Reference

Precocious anaphase is seen in homozygous mei-217^r1 or mei-217^g10 mature oocytes. In mei-217^r1 mei-41^D18 or mei-217^g10 mei-41^D18 double mutants a metaphase arrest is almost always seen in mature oocytes (as occurs in wild type).

(Liu et al., 2000)

No precocious anaphases are seen in mutant oocyte nuclei. In the progeny of homozygous mei-41^D18 mothers, there is a high frequency of nullo-X gametes compared to diplo-X gametes.

(McKim et al., 2000)

Eggs are laid.

(Mohler and Carroll, 1984)

Hemizygous male larvae are sensitive to HN2 and MMS.

(Mason et al., 1981)

Homozygous females lay eggs that fail to hatch.

(Mohler, 1977)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

mei-41^D18 is a suppressor of abnormal meiotic cell cycle | recessive phenotype of mei-217^g10

(Liu et al., 2000)

mei-41^D18 is a suppressor of abnormal meiotic cell cycle | recessive phenotype of mei-217^r1

(Liu et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

mei-41^D18 has phenotype, suppressible by mei-P22^P22

(McKim et al., 2000)

NOT suppressed by

Statement

Reference

mei-41^D18 has phenotype, non-suppressible by mei-218¹

(McKim et al., 2000)

mei-41^D18 has phenotype, non-suppressible by mei-9^a

(McKim et al., 2000)

Suppressor of

Statement

Reference

mei-41^D18 is a suppressor of meiosis I | female phenotype of mei-217^g10

(Liu et al., 2000)

mei-41^D18 is a suppressor of meiosis I | female phenotype of mei-217^r1

(Liu et al., 2000)

Other

Statement

Reference

c(3)G⁶⁸, mei-41^D18 has oocyte nucleus & meiotic cell cycle phenotype

(McKim et al., 2000)

mei-41^D18, mei-9^a has oocyte nucleus & meiotic cell cycle phenotype

(McKim et al., 2000)

mei-41^D18, mei-P22^P22 has oocyte nucleus & meiotic cell cycle phenotype

(McKim et al., 2000)

mei-41[+]/mei-41^D18, mei-9^a has oocyte nucleus & meiotic cell cycle phenotype

(McKim et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

About a quarter of nuclei in mei-9^a/mei-9^a; mei-41^D18/+ oocytes exhibit premature anaphase (or later) meioses. In mei-41^D18; mei-218¹ oocytes no premature anaphases are seen. In mei-41^D18; mei-P22^P22 oocyte nuclei premature anaphases are seen. In mei-41^D18; c(3)G⁶⁸ oocyte nuclei premature anaphases are seen. The addition of homozygous mei-P22^P22 partially suppresses the high frequency of nullo-X gametes compared to diplo-X gametes seen in the progeny of homozygous mei-41^D18 mothers but the addition of homozygous mei-218¹ or mei-9^a does not.

(McKim et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

(Mohler, 1977)

(Mohler, 1977)

(Mohler, 1977)

(Mohler, 1977)

(Mohler, 1977)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

The semi-lethality of the "mei-41^D18" chromosome may be due to mutations at other loci and not at mei-41, because mei-41^D18 is viable in combination with other semi-lethal mei-41 mutant chromosomes.

(Laurencon et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

12-1007

(Mohler, 1977)

fs(1)M37^12-1007

(Mohler and Carroll, 1984)

mei-41^12-1007

(Mason et al., 1981)

mei-41^D18

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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