FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mhc8
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General Information
Symbol
Dmel\Mhc8
Species
D. melanogaster
Name
FlyBase ID
FBal0012249
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    antimorphic allele - genetic evidence

    (Homyk and Emerson, 1988)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Y829H.

    (Bernstein and Zhang, 1999.11.18)

    Nucleotide substitution: T?C. Amino acid replacement: Y?H. Mutation is in exon 12, in the region that binds the regulatory light chain.

    (Kronert et al., 1999)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:16,780,751..16,780,751 [+]
    Nucleotide change:

    T16780751C

    Reported nucleotide change:

    T?C

    Amino acid change:

    Y829H | Mhc-PA; Y829H | Mhc-PB; Y829H | Mhc-PC; Y829H | Mhc-PD; Y829H | Mhc-PE; Y829H | Mhc-PF; Y829H | Mhc-PG; Y829H | Mhc-PH; Y829H | Mhc-PI; Y829H | Mhc-PK; Y829H | Mhc-PL; Y829H | Mhc-PM; Y829H | Mhc-PN; Y829H | Mhc-PO; Y829H | Mhc-PP; Y829H | Mhc-PQ; Y829H | Mhc-PR; Y829H | Mhc-PS; Y829H | Mhc-PT; Y829H | Mhc-PU; Y829H | Mhc-PV

    Reported amino acid change:

    Y829H

    (Bernstein and Zhang, 1999.11.18, Kronert et al., 1999)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygotes have an indented thorax, upheld wings, and are flightless.

        (Homyk and Emerson, 1988)

        Heterozygotes display indented thorax and erect wings. Judged to be antimorphic since not rescued by addition of Dp(2;3)osp3. Mhc8 interaction in double heterozygotes with other flightless mutants observed by Homyk and Emerson (1988). Heterozygous viability severely reduced in combination with either heterozygous or hemizygous wupAhdp-2, upint-3 and up101; lethal in upx/Y males. No interaction with the following: wupAhdp-3, wupAhdp-4, wupAhdp-5, wupAhdp-101, fliH1, up2 or up3.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT Suppressor of
        Statement
        Reference

        Mhc8 is a non-suppressor of phenotype of wupAhdp-2

        (Kronert et al., 1999)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The heldout wing defects of wupAhdp-2 flies are not suppressed by Mhc8.

        (Kronert et al., 1999)

        Lethal in double heterozygous combination with up101, upint-3 or wupAhdp-2.

        (Homyk and Emerson, 1988)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially complements

        MhcD45

        (Kronert et al., 1999)
        Fails to complement

        MhcD41

        (Kronert et al., 1999)

        Mhc1

        (Kronert et al., 1999)
        Comments

        MhcD45 produces very few viable adults in combination with Mhc8.

        (Kronert et al., 1999)

        The dominant phenotype is not rescued by Dp(2;3)osp3, which carries a duplication of the Mhc gene, suggesting this allele is an antimorph.

        (Homyk and Emerson, 1988)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Mogami.

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Ifm(2)3
        (Fyrberg et al., 1988, Homyk and Emerson, 1988)
        Mhc8
        Name Synonyms
        Secondary FlyBase IDs
          References (6)