FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mhc9
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General Information
Symbol
Dmel\Mhc9
Species
D. melanogaster
Name
FlyBase ID
FBal0012250
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Kronert et al., 1994)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: E482K. E482K results in a charge change encoded by alternative exon 9a.

    (Kronert et al., 1994)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:16,775,250..16,775,250 [+]
    Nucleotide change:

    G16775250A

    Amino acid change:

    E482K | Mhc-PK; E482K | Mhc-PL

    Reported amino acid change:

    E482K

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Kronert et al., 1994)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Lack of thick filaments in the indirect flight muscles and a greatly reduce number in the small cells of the jump muscles. Lack of thick filaments is not due to aberrant interactions with thin filaments nor poisoning of wild type thick filaments.

        (Kronert et al., 1994)

        Mhc accumulation in leg muscles is unaffected and the effect on thick filament accumulation in the jump muscle is less severe then Mhc10.

        (Collier et al., 1990)

        Indirect flight muscles accumulate little or no MHC, have no thick filaments, and show no organized myofibrils. The four smaller cells of the TDT display reduction in thick filament number and myofibril size; large TDT cells unaffected. Flies jump 59% as well as wild type. Leg muscle MHC found in normal amounts (O'Donnell, Collier, Mogami and Bernstein, 1989). homozygous viable

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Mogami.

        Comments
        Comments

        Exons 15a and 15b have been sequenced and are wild-type.

        (Collier et al., 1990)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Mhc9
        Name Synonyms
        Secondary FlyBase IDs
          References (4)