FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mhc16
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General Information
Symbol
Dmel\Mhc16
Species
D. melanogaster
Name
FlyBase ID
FBal0012257
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes have an indented thorax, upheld wings, and are flightless. Hemizygotes are semi-lethal. They are very inactive, with weak mesothoracic legs that are generally folded beneath the thorax, and die prematurely after eclosion.

Heterozygotes display indented thorax and erect wings; flightless; hemizygotes semi-lethal, very inactive, have weak mesothoracic legs which are generally folded beneath the thorax; die prematurely after eclosion. Judged to be antimorphic since not rescued by addition of Dp(2;3)osp3. Mhc16 interaction in double heterozygotes with other flightless mutants observed by Homyk and Emerson (1988). Heterozygous viability severely reduced in combination with hemizygous wupAhdp-2, upint-3, up101; or upx; rare escapers have gnarled legs, walk poorly and die within two days of eclosion.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The dominant phenotype is not rescued by Dp(2;3)osp3, which carries a duplication of the Mhc gene, suggesting this allele is an antimorph.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Homyk.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
No upward flight
Secondary FlyBase IDs
    References (2)