FB2026_02 , released June 18, 2026
Allele: Dmel\mus208B1
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General Information
Symbol
Dmel\mus208B1
Species
D. melanogaster
Name
FlyBase ID
FBal0012629
Feature type
allele
Associated gene
mus208
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae derived from homozygous females show greater sensitivity to methyl methanesulfonate (MMS) than homozygous larvae derived from heterozygous females.

      (Henderson and Grigliatti, 1992)

      Larval survival hypersensitive to exposure to methyl methanesulfonate, N-acetyl-2-aminofluorene and benzoapyrene; slight allele-specific sensitivity to nitrogen mustard and gamma rays.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Viable in double homozygous combination with mus201D1, mus205B1, mus210B1 or mus211B1. mus208B1 mus210B1 mus211B1 triple homozygotes show 89% viability compared to controls. mus208B1 mus210B1 mus211B2 triple homozygotes show 88% viability compared to controls. mus205B1 mus208B1 double mutant larvae are no more sensitive to methyl methanesulfonate (MMS) than mus205B1 single mutant larvae. mus201D1 shows a fairly strong synergistic interaction with respect to sensitivity to methanesulfonate (MMS) in combination with either mus208B1 or mus210B1. mus208B1 mus210B1 mus211B2 triple homozygotes are sensitive to MMS, ethyl methanesulfonate, N-nitrosodimethylamine, diethylnitrosamine, nitrosomethyl urea and N-methyl-N'-nitro-N-nitrosoguanidine, formaldehyde, cyclophosphamide, diepoxybutane, benzoapyrene, benzoepyrene and hexamethylphosphoramide compared to controls. mus205B1 mus208B1 mus210B1 triple homozygotes are sensitive to MMS, ethyl methanesulfonate, N-nitrosodimethylamine and diethylnitrosamine compared to controls.

      (Henderson and Grigliatti, 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mus208B1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)