FlyBase Allele Report: Dmel\Xpc[B1]

General Information

Symbol

Dmel\Xpc^B1

Species

D. melanogaster

Name

FlyBase ID

FBal0012632

Feature type

allele

Associated gene

Dmel\Xpc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Description

Nonsense mutation.

(Sekelsky, 1999.9.21)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:15,312,097..15,312,097 [+]

Nucleotide change:

C15312097T

Reported nucleotide change:

C593T|FBrf0124909

Amino acid change:

Q84term | Xpc-PA; Q85term | Xpc-PC; Q85term | Xpc-PD

Comment:

Amino acid change coordinates are for Xpc- PA

(Sekelsky, 1999.9.21)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal DNA repair | larval stage

(Lindsley and Zimm, 1992)

chemical sensitive | larval stage

(Lindsley and Zimm, 1992)

chemical sensitive | maternal effect

(Henderson and Grigliatti, 1992)

fertile

(Henderson and Grigliatti, 1992)

viable

(Henderson and Grigliatti, 1992)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous larvae derived from homozygous females show greater sensitivity to methyl methanesulfonate (MMS) than homozygous larvae derived from heterozygous females.

(Henderson and Grigliatti, 1992)

Larval survival hypersensitive to exposure to methyl methanesulfonate, N-acetyl-2-aminofluorene, and benzo^apyrene, moderately sensitive to nitrogen mustard and insensitive to gamma rays. Excision of pyrimidine dimers impaired; 4-5 fold decrease in activity of ultra-violet-specific endonuclease observed in primary cell cultures.

(Lindsley and Zimm, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Xpc^B1, mus201^D1 has viable phenotype

(Henderson and Grigliatti, 1992)

Xpc^B1, mus201^D1 has chemical sensitive phenotype

(Henderson and Grigliatti, 1992)

Xpc^B1, mus211^B1 has viable phenotype

(Henderson and Grigliatti, 1992)

Xpc^B1, mus211^B1 has chemical sensitive phenotype

(Henderson and Grigliatti, 1992)

PolZ1^A1, Xpc^B1, mus208^B1 has chemical sensitive phenotype

(Henderson and Grigliatti, 1992)

PolZ1^B1, Xpc^B1 has viable phenotype

(Henderson and Grigliatti, 1992)

Xpc^B1, mus208^B1 has viable phenotype

(Henderson and Grigliatti, 1992)

Xpc^B1, mus208^B1 has chemical sensitive phenotype

(Henderson and Grigliatti, 1992)

Xpc^B1, mus208^B1, mus211^B1 has viable phenotype

(Henderson and Grigliatti, 1992)

Xpc^B1, mus208^B1, mus211^B2 has viable phenotype

(Henderson and Grigliatti, 1992)

Xpc^B1, mus208^B1, mus211^B2 has chemical sensitive phenotype

(Henderson and Grigliatti, 1992)

PolZ1^B1, Xpc^B1, mus208^B1 has chemical sensitive phenotype

(Henderson and Grigliatti, 1992)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Viable in double homozygous combination with mus201^D1, mus205^B1, mus208^B1 or mus211^B1. mus208^B1 mus210^B1 mus211^B1 triple homozygotes show 89% viability compared to controls. mus208^B1 mus210^B1 mus211^B2 triple homozygotes show 88% viability compared to controls. mus205^B1 mus210^B1 double mutant larvae are no more sensitive to MMS than mus205^B1 single mutant larvae. mus210^B1 and mus211^B1 show a fairly strong synergistic interaction with respect to sensitivity to methanesulfonate (MMS). mus201^D1 shows a fairly strong synergistic interaction with respect to sensitivity to methanesulfonate (MMS) in combination with either mus208^B1 or mus210^B1. mus208^B1 mus210^B1 mus211^B2 triple homozygotes are sensitive to MMS, ethyl methanesulfonate, N-nitrosodimethylamine, diethylnitrosamine, nitrosomethyl urea and N-methyl-N'-nitro-N-nitrosoguanidine, formaldehyde, cyclophosphamide, diepoxybutane, benzo^apyrene, benzo^epyrene and hexamethylphosphoramide compared to controls. mus205^B1 mus208^B1 mus210^B1 triple homozygotes are sensitive to MMS, ethyl methanesulfonate, N-nitrosodimethylamine and diethylnitrosamine compared to controls.

(Henderson and Grigliatti, 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Xpc^G1

(Sekelsky et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF209743

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Xpc^B1

mus210^B1

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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