FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Xpc
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General Information
Symbol
Dmel\Xpc
Species
D. melanogaster
Name
Xeroderma pigmentosum, complementation group C
Annotation Symbol
CG8153
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004698
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Xeroderma pigmentosum, complementation group C (Xpc) encodes a protein involved in recognition of DNA damage and recruitment of nucleotide excision repair proteins. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

mus210, mus(2)201, Xpcc

Key Links
Genomic Location
Cytogenetic map
51F4-51F5
Sequence location
Recombination map
2-74
RefSeq locus
NT_033778 REGION:15311510..15318239
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables damaged DNA binding
inferred from sequence or structural similarity with SGD:S000000964
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR004583
(InterPro Project Members, 2004-)
enables DNA binding
inferred from electronic annotation with InterPro:IPR018326, InterPro:IPR018327, InterPro:IPR018328
(InterPro Project Members, 2004-)
enables DNA damage sensor activity
inferred from biological aspect of ancestor with PANTHER:PTN000253194
(GO Reference Genome Project, 2011-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in meiotic mismatch repair involved in reciprocal meiotic recombination
inferred from genetic interaction with FLYBASE:Msh6; FB:FBgn0036486
(Crown et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mismatch repair
inferred from biological aspect of ancestor with PANTHER:PTN000253194
(GO Reference Genome Project, 2011-)
involved_in nucleotide-excision repair
inferred from sequence or structural similarity
(Henning et al., 1994)
inferred from electronic annotation with InterPro:IPR004583
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with SGD:S000000964
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000253194
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytosol
inferred from sequence or structural similarity with SGD:S000000964
(Gene Ontology Curators, 2002-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000253194
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from electronic annotation with InterPro:IPR004583
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with SGD:S000000964
(Gene Ontology Curators, 2002-)
part_of XPC complex
inferred from biological aspect of ancestor with PANTHER:PTN000253197
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the XPC family. (Q24595)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Xeroderma pigmentosum, complementation group C (Xpc) encodes a protein involved in recognition of DNA damage and recruitment of nucleotide excision repair proteins. [Date last reviewed: 2019-03-21]
Protein Function (UniProtKB)
Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity). Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
(UniProt, Q24595)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
mus210
Larval survival hypersensitive to exposure to methyl methanesulfonate, N-acetyl-2-aminofluorene, and benzo[a]-pyrene, moderately sensitive to nitrogen mustard, and insensitive to gamma rays. Excision of pyrimidine dimers impaired; 4-5 fold decrease in activity of ultra-violet-specific endonuclease observed in primary cell cultures.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Xpc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24595)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.39

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Xpc-RA
FBtr0087374
NM_057513
4275
1293
Xpc-RC
FBtr0087373
NM_166087
4683
1294
Xpc-RD
FBtr0308700
NM_001259407
1390
330
Additional Transcript Data and Comments
Reported size (kB)

4.2 (longest cDNA)

(Henning et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Xpc-PA
FBpp0086506
144.2
1293
9.92
Q24595
NP_476861
AAF58150
Xpc-PC
FBpp0086505
144.3
1294
9.92
NP_725451
AAM68530
Xpc-PD
FBpp0300906
35.3
330
5.37
A0A0B4K739
NP_001246336
AFH08090
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

1293 (aa)

(Henning et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Heterodimer.

(UniProt, Q24595)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Xpc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.56

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Xpc in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Xpc
Transgenic constructs containing regulatory region of Xpc
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\XPC
11 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Xpc
12 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Xpc
10 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\xpc
8 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\xpc
11 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\xpc-1
10 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP003345
10 of 12
Yes
Yes
Agam\AgaP_AGAP002106
8 of 12
No
Yes
Agam\AgaP_AGAP003342
8 of 12
No
Yes
Agam\AgaP_AGAP001967
6 of 12
No
Yes
Agam\AgaP_AGAP012599
6 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\RAD4
9 of 13
Yes
Yes
Atha\CHR8
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\RAD4
9 of 13
Yes
Yes
Scer\RAD34
2 of 13
No
Yes
Scer\RAD26
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\rhp42
9 of 12
Yes
Yes
Spom\rhp41
8 of 12
No
Yes
Spom\rhp26
1 of 12
No
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Xpc. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    XPC; XPC complex subunit, DNA damage recognition and repair factor
    11 of 14
    613208
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Heterodimer.
    (UniProt, Q24595 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-74
    Cytogenetic map
    51F4-51F5
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    51F4-51F5
    Limits computationally determined from genome sequence between P{PZ}scb01288 and P{lacW}dupk03308
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    51F-51F
    (Sekelsky, 2000, Sekelsky, 1999.12.1)
    Experimentally Determined Recombination Data
    Location

    2-74

    (FlyBase, 2016)

    2-78.0

    (Comeron et al., 2012)

    2-73.8 +/- 2.5

    (Khromykh and Zakharow, 1981)

    2-69.1

    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (6)
    Genomic Clones (24)
    cDNA Clones (78)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        Involved in pre-replication DNA repair of UV and AA lesions.

        (de Buendia, 1998)

        The Drosophila homolog of the human XPC gene is cloned and the C-terminal 346 amino acids of the predicted polypeptide share significant homology with similar regions of both the translated human XPC and yeast RAD4 genes.

        (Henning et al., 1994)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: mus210 Xpcc

        (Sekelsky, 1999.9.21)
        Additional comments
        Nomenclature History
        Source for database identify of

        Source for identity of: Xpc mus210

        (Crown et al., 2014)
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (20)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 59 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        References (84)