FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\XpcG1
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General Information
Symbol
Dmel\XpcG1
Species
D. melanogaster
Name
FlyBase ID
FBal0012633
Feature type
allele
Associated gene
Dmel\Xpc
Associated Insertion(s)
Carried in Construct
Also Known As
mus(2)201G1, mus(2)201G1
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nonsense mutation.

    (Sekelsky, 1999.9.21)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:15,312,200..15,312,200 [+]
    Nucleotide change:

    C15312200A

    Reported nucleotide change:

    C593A|FBrf0124909

    Amino acid change:

    S118term | Xpc-PA; S119term | Xpc-PC; S119term | Xpc-PD

    Comment:

    Amino acid change coordinates are for Xpc- PA

    (Sekelsky, 1999.9.21)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutants do not show sensitivity to colchicine, griseofulvin or vinblastine.

        (Shvartsman and Isaenko, 1999)

        mus210G1 reduces the level of phenocopies of ey mutations produced by larvae treated with griseofulvin.

        (Isaenko et al., 1994)

        Homozygous larvae show a significantly higher sensitivity to analgin, amidopirine and antipirine compared to heterozygotes. The relative sensitivity of the homozygotes increases as the concentration of analgin, amidopirine or antipirine is increased.

        (Mikheev and Imianitov, 1990)

        Early and late larvae show extremely high sensitivity to the lethal action of methyl methanesulfonate and UV light. The rate of excision of UV-induced pyrimidine dimers is significantly lower than wild-type in primary embryonic cell cultures. These cells show a 4-5 fold decrease in UV-specific endonuclease activity.

        (Luchkina et al., 1982)

        Larvae are supersensitive to methyl methanesulfonate.

        (Khromykh and Zakharow, 1981)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 1 )
        Crossreferences
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        Synonyms and Secondary IDs (8)
        Reported As
        Symbol Synonym
        XPCG1
        (Deger et al., 2022)
        XpcG1
        (Crown et al., 2014)
        mus(2)201G1
        (Sekelsky et al., 2000, Shvartsman and Romashkina, 1995)
        mus(2)201G1
        (Shvartsman and Isaenko, 1999, Isaenko et al., 1994)
        mus201
        (Levina, 1995)
        mus201G1
        mus210G1
        rad202
        Name Synonyms
        Secondary FlyBase IDs
        • FBal0012621
        References (13)