FB2026_02 , released June 18, 2026
Allele: Dmel\mus302D1
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General Information
Symbol
Dmel\mus302D1
Species
D. melanogaster
Name
FlyBase ID
FBal0012641
Feature type
allele
Associated gene
Dmel\mus302
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Carvajal-Garcia et al., 2020)

amorphic allele - molecular evidence

(Carvajal-Garcia et al., 2020)
Mutagen
ethyl methanesulfonate
(Boyd et al., 1981)
Progenitor genotype
Cytology
Description

Amino acid replacement: V303E.

(Carvajal-Garcia et al., 2020)

Nucleotide substitution: T908A.

(Carvajal-Garcia et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:16,778,574..16,778,574 [-]
Nucleotide change:

T16778574A

Reported nucleotide change:

T908A

Amino acid change:

V303E | mus302-PA; V303E | mus302-PB

Reported amino acid change:

V303E

(Carvajal-Garcia et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mus302D1 and mus302D1/mus302Z1882 mutants are sensitive to 0.025% MMS.

      (Carvajal-Garcia et al., 2020)

      Excision repair capacity is partly deficient and post-replication repair capacity is deficient.

      (Ferro and Eeken, 1993)

      Mutants exhibit normal photorepair capacity.

      (Harris and Boyd, 1993)

      Flies are sensitive to X rays.

      (Oliveri et al., 1990)

      Hypersensitive to methyl methanesulfonate. Sensitive to 0.008% HN2.

      (Boyd et al., 1981)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      mus302D1/mus302Z1882 has chemical sensitive phenotype, enhanceable by spn-A093A/spn-A3

      (Carvajal-Garcia et al., 2020)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but shows a significant enhancement of meiotic drive in these flies compared to controls.

      (McKee et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Boyd.

      Comments
      Comments

      Homozygotes have reduced levels of excision and postreplication repair compared to wild-type. Homozygous cultured cells respond to UV irradiation with unusually low thymidine incorporation and with the synthesis of abnormally short nascent DNA.

      (Brown and Boyd, 1981)

      The recovery of chromosomes undergoing P-element transposition is severely reduced in homozygous mus302D1 and mus302D1/mus302D2 flies, suggesting that mus302+ function is required for the recovery of these chromosomes.

      (Banga et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      302D1
      (McKee et al., 2000)
      mus(3)302D1
      (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Miyamoto, 1990)
      mus302D1
      (Carvajal-Garcia et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (12)