FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ndl6
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General Information
Symbol
Dmel\ndl6
Species
D. melanogaster
Name
FlyBase ID
FBal0012926
Feature type
allele
Associated gene
Dmel\ndl
Associated Insertion(s)
Carried in Construct
Also Known As
ndl260
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(LeMosy and Hashimoto, 2000)
Mutagen
ethyl methanesulfonate
(Hong and Hashimoto, 1996, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G4112A. Mutation is within the catalytic domain.

(LeMosy et al., 2000)

The protease domain of this allele has been sequenced. Amino acid replacement: G1282R. Residue G1282 is a highly conserved glycine in the core structure of the serine protease. Nucleotide substitution: a G to A transition.

(Hong and Hashimoto, 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:6,598,600..6,598,600 [-]
Nucleotide change:

G6598600A

Reported nucleotide change:

G?A

Amino acid change:

G1282R | ndl-PA

Reported amino acid change:

G1282R

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Residue G1282 is a highly conserved glycine in the core structure of the serine protease.

(LeMosy et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In eggs from mutant mothers, the vitelline membrane is permeable to Neutral red dye.

      (LeMosy and Hashimoto, 2000)

      Allele is inactive in dorsoventral polarity establishment.

      (LeMosy et al., 2000)

      Class II allele. Affected embryos show dorsalization. Eggs are somewhat fragile.

      (Hong and Hashimoto, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double mutant combinations with eaD3 are strongly dorsalized.

      (Chasan et al., 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Class II allele.

      (LeMosy et al., 2000)

      Fails to complement Class I ndl alleles.

      (Hong and Hashimoto, 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (8)