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General Information
Symbol
Dmel\ninaA2
Species
D. melanogaster
Name
FlyBase ID
FBal0012960
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ninaAP263
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C877620T

Reported nucleotide change:

C693T

Amino acid change:

Q87term | ninaA-PA

Reported amino acid change:

Q87term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: C692T.

Amino acid replacement: Q87term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous flies and mosaic flies in which the retinal tissue is homozygous for ninaA2 but the rest of the animal is ninaA+ lack the prolonged depolarising afterpotential (PDA) in the electroretinogram response.

Mutants exhibit excessive endoplasmic reticulum (ER) in photoreceptor cells that is dependent on expression of rhodopsin gene. The ninaE+/ninaED1 or the ninaE+/ninaED2 heterozygous genotypes do not prevent the accumulation of ER present in ninaA2 flies.

With respect to defective PDA, ninaA2 > ninaA1 > ninaA3.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Pak.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (9)