FlyBase Allele Report: Dmel\ninaE[1]

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Allele: Dmel\ninaE¹

General Information

Symbol

Dmel\ninaE¹

Species

D. melanogaster

Name

FlyBase ID

FBal0013006

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

ninaE^ora, ora^JK84, ninaE^JK84, ora

Key Links

Genomic Maps

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Pollock et al., 1995)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Amino acid replacement: Q251term.

(Kurada and O'Tousa, 1995, Washburn and O'Tousa, 1992)

Gln²⁵¹ --> stop

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

3R:19,886,984..19,886,984 [-]

Nucleotide change:

C19886984T

Amino acid change:

Q251term | ninaE-PA

Reported amino acid change:

Q251term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kurada and O'Tousa, 1995, Washburn and O'Tousa, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal phototaxis | wandering third instar larval stage

(Sawin-McCormack et al., 1995)

abnormal thermotaxis | larval stage | temperature conditional

(Shen et al., 2011)

Phenotype Manifest In

(Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995)

rhabdomere R1 & microvillus

(Pollock et al., 1995)

(Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995)

rhabdomere R2 & microvillus

(Pollock et al., 1995)

(Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995)

rhabdomere R3 & microvillus

(Pollock et al., 1995)

(Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995)

rhabdomere R4 & microvillus

(Pollock et al., 1995)

(Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995)

rhabdomere R5 & microvillus

(Pollock et al., 1995)

(Yasuyama and Meinertzhagen, 1999, Pollock et al., 1995)

rhabdomere R6 & microvillus

(Pollock et al., 1995)

Detailed Description

Statement

Reference

Mutant larvae show defects in discrimination between 18[o]C and 24[o]C in a binary choice thermotaxis assay compared to controls, but discrimination between 18[o]C and cooler or very warm temperatures is normal.

(Shen et al., 2011)

ninaE¹ mutant class IV dendritic arborization neurons do not exhibit any defects in light response.

(Xiang et al., 2010)

The effect of anoxia as measured in the eye by extracellular voltage change recordings is similar to that of wild type.

(Agam et al., 2000)

The eyelet maintains well-developed rhabdomeres even 1 week after eclosion in mutant flies, although degeneration of ommatidial rhabdomeres R1-R6 is seen.

(Yasuyama and Meinertzhagen, 1999)

The whole cell capacitance of photoreceptor cells remains relatively small throughout development, in contrast to wild-type. The magnitude of the rundown current (RDC) is larger than wild-type at all developmental stages. R1 to R6 photoreceptor cells have more microvilli per rhabdomere than wild-type flies and membrane loops at the base of the microvilli are enlarged compared to wild-type.

(Pollock et al., 1995)

Third instar foraging larvae show negative photobehaviour indistinguishable from the wild-type response to light. Third instar larvae continue to show negative phototaxis during the wandering stage, in contrast to wild-type larvae.

(Sawin-McCormack et al., 1995)

induced with ort¹ as "ora^JK84"; ca 10^-6 normal RH1 level

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

HisCl1¹³⁴, ninaE¹, ort¹ has abnormal phototaxis phenotype, enhanceable by ort^{UAS.2x.Tag:HA}/Scer\GAL4^DBD.C1a.ort/Hsim\VP16^{AD-VGlut1-OK371}

(Karuppudurai et al., 2014)

HisCl1¹³⁴, ninaE¹, ort⁴/ort¹ has abnormal phototaxis phenotype, enhanceable by ort^{UAS.2x.Tag:HA}/Scer\GAL4^DBD.C1a.ort/Hsim\VP16^{AD-VGlut1-OK371}

(Karuppudurai et al., 2014)

HisCl1¹³⁴, ninaE¹, ort⁶/ort¹ has abnormal phototaxis phenotype, enhanceable by ort^{UAS.2x.Tag:HA}/Scer\GAL4^DBD.C1a.ort/Hsim\VP16^{AD-VGlut1-OK371}

(Karuppudurai et al., 2014)

Other

Statement

Reference

HisCl1¹³⁴, ninaE¹, ort¹ has abnormal phototaxis phenotype

(Karuppudurai et al., 2014)

HisCl1¹³⁴, ninaE¹, ort⁴/ort¹ has abnormal phototaxis phenotype

(Karuppudurai et al., 2014)

HisCl1¹³⁴, ninaE¹, ort⁶/ort¹ has abnormal phototaxis phenotype

(Karuppudurai et al., 2014)

ninaE¹, ort¹ has abnormal locomotor behavior phenotype

(Strauss et al., 2001)

Phenotype Manifest In

Suppressor of

Statement

Reference

ninaE¹ is a suppressor of phenotype of norpA^P24

(Kurada and O'Tousa, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

ort¹ in a HisCl1¹³⁴, ninaE¹ mutant background significantly reduces the phototactic preference for ultraviolet light over green light seen in wild type and control flies.

ort¹/ort⁴ in a HisCl1¹³⁴, ninaE¹ mutant background significantly reduces the phototactic preference for ultraviolet light over green light seen in wild type and control flies.

ort¹/ort⁶ in a HisCl1¹³⁴, ninaE¹ mutant background significantly reduces the phototactic preference for ultraviolet light over green light seen in wild type and control flies.

Expressing ort^{Scer\UAS.2x.T:Ivir\HA1} in Tm5c neurons in a homozygous ort¹, ort¹/ort⁴, ort¹/ort⁶ background (with HisCl1¹³⁴ and ninaE¹) under the control of Scer\GAL4^{C1a.DBD.ort.T:Zzzz\ZipRREEL} and Hsim\VP16^{AD.VGlut.OK371.T:Zzzz\ZipEERRL,T:SV40\nls2} enhances the preference for green light over UV seen in the mutant flies alone.

(Karuppudurai et al., 2014)

ninaE¹ ort¹ flies show residual object fixation in tethered flight, but no more than 16% of the residual object fixation is accomplished with wingbeat steering (the predominant steering mechanism of normal flies). ninaE¹ ort¹ flies are significantly impaired in the ability to maintain their orientation towards a landmark when walking in the Buridan's paradigm assay. Their average and maximum walking speed are reduced to about one-half of the corresponding speed observed under identical conditions in wild-type flies.

(Strauss et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

1946

w^*; ort¹ ninaE¹

106595

w^*; ort¹ ninaE¹

Notes on Origin

Discoverer

Koenig.

Comments

Comments

Photolysis of the caged Ca²⁺ compounds DM-nitrophen and nitr-5 induces a small inward current with no detectable latency in ninaE¹ photoreceptor cells.

(Hardie, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Q251@

(Bentrop, 1998)

ninaE¹

(Schnaitmann et al., 2024, Pagni et al., 2021, Schnaitmann et al., 2018, Karuppudurai et al., 2014, Shen et al., 2011, Xiang et al., 2010)

ninaE^JK84

(Kurada and O'Tousa, 1995, Sawin-McCormack et al., 1995)

ninaE^ora

(Agam et al., 2000, Yasuyama and Meinertzhagen, 1999, Yang et al., 1998, Shim et al., 1997, Hardie, 1996, Lee et al., 1996, Hardie, 1995, Pollock et al., 1995, Stark et al., 1995)

ninaE^oraJK84

(Arnon et al., 1997)

ora

(Hardie, 1995, Washburn and O'Tousa, 1992)

ora^JK84

(Yasuhara et al., 2000, Kurada et al., 1995)

Name Synonyms

Secondary FlyBase IDs

FBal0050199

References (27)

Report Sections