FB2026_02 , released June 18, 2026
Allele: Dmel\nodDR3
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General Information
Symbol
Dmel\nodDR3
Species
D. melanogaster
Name
FlyBase ID
FBal0013073
Feature type
allele
Associated gene
Dmel\nod
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Rasooly et al., 1991)
Mutagen
ethyl methanesulfonate
(Rasooly et al., 1994, Rasooly et al., 1991)
Progenitor genotype
nodDTW
(Rasooly et al., 1994, Rasooly et al., 1991)
Cytology
Description

Transition is in the putative microtubule-binding domain of the predicted nod protein.

(Rasooly et al., 1994)

Nucleotide substitution: G?A.

(Rasooly et al., 1994)

Nucleotide substitution: G649A. Amino acid replacement: R194H. Mutation lies within the putative microtubule binding domain.

(Rasooly et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,581,638..11,581,638 [+]
Nucleotide change:

G11581638A

Reported nucleotide change:

G649A

Amino acid change:

R194H | nod-PA; R194H | nod-PB

Reported amino acid change:

R194H

(Rasooly et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Severe alleles of nod reduce the transmission of the Dp(1;f)1187 derivative P{PZ}8-23 more than weaker alleles (nodDTW > nodDR3 >= nod3).

      (Murphy and Karpen, 1995)

      Intragenic suppressor of nodDTW.

      (Rasooly et al., 1994)

      Second site intragenic suppressor of nodDTW.

      (Rasooly et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Reversion of segregation defects and cold sensitive lethality.

      (Rasooly et al., 1991)

      Reversion of the cold-sensitive lethality and partial reversion of the dominant meiotic phenotype.

      (Rasooly et al., 1994)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      nodDR3
      Name Synonyms
      Secondary FlyBase IDs
        References (3)