Single base change in the mechanochemical domain which affects the highly conserved putative ATP-binding/hydrolysis domain. Nucleotide substitution: G352A. Amino acid replacement: S94N. It is unlikely there is an additional mutation in the regulatory region although this region was not sequenced.
lwr05486 or lwr5 dominantly suppress the nondisjunction phenotype of nodDTW females. nodDTW mei-2181 double homozygous females show 60% X chromosome nondisjunction and 63% 4th chromosome nondisjunction. Oocyte spindles are often frayed or oddly shaped, or multiple spindles are present. These defects are suppressed by lwr05486/+.