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General Information
Symbol
Dmel\nodDTW
Species
D. melanogaster
Name
Dominant Ted Wright
FlyBase ID
FBal0013072
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G11581268A

Reported nucleotide change:

G352A

Amino acid change:

S94N | nod-PA; S94N | nod-PB

Reported amino acid change:

S94N

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Single base change in the mechanochemical domain which affects the highly conserved putative ATP-binding/hydrolysis domain. Nucleotide substitution: G352A. Amino acid replacement: S94N. It is unlikely there is an additional mutation in the regulatory region although this region was not sequenced.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

meiosis & nuclear chromosome | female

Detailed Description
Statement
Reference

Heterozygous females show high rates of nondisjunction (57%) for the 4th chromosome and 0.8% nondisjunction for the X chromosome.

Dominant meiotic phenotype varies with dosage and temperature: at 25oC only non-exchange chromosomes undergo nondisjunction and loss, at lower temperatures segregation of both exchange and nonexchange chromosomes is affected.

Severe alleles of nod reduce the transmission of the Dp(1;f)1187 derivative P{PZ}8-23 more than weaker alleles (nodDTW > nodDR3 >= nod3).

Dominant meiotic mutation. The effect of E(DTW) is dose-dependent, one copy enhances the phenotype while two copies renders the fly nearly sterile.

Defects in meiotic and mitotic chromosome segregation. At 23.5oC heterozygous females exhibit the meiotic defect of abnormal segregation of nonexchange chromosomes. At 18oC in homozygous or heterozygous females the meiotic defect is more severe causing defects in the segregation of both exchange and nonexchange chromosomes. Homozygous and hemizygous males exhibit mitotic defects including somatic chromosome breakage and loss. A single dose of nodDTW is not sufficient to cause cold sensitivity, whether or not wild type protein is present.

Reduced survival when raised at 17oC compared with that when raised at 25oC; the differences in survival at the two temperatures vary substantially among replicate crosses. embryonic lethal female-sterile at 16oC

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

nodDTW has phenotype, enhanceable by mwr1

nodDTW has phenotype, enhanceable by mwr2

nodDTW has phenotype, enhanceable by mwr3

nodDTW has phenotype, enhanceable by mwr4

nodDTW has phenotype, enhanceable by mwra

Suppressed by
Statement
Reference

nodDTW has meiosis & nuclear chromosome | female phenotype, suppressible by lwr5/lwr[+]

nodDTW has meiosis & nuclear chromosome | female phenotype, suppressible by lwr05486/lwr[+]

mei-2181, nodDTW has meiosis & nuclear chromosome | female phenotype, suppressible by lwr05486

mei-2181, nodDTW has oocyte & spindle phenotype, suppressible by lwr05486

nodDTW has phenotype, suppressible by lwr05486

Other
Statement
Reference

mei-2181, nodDTW has meiosis & nuclear chromosome | female phenotype

mei-2181, nodDTW has oocyte & spindle phenotype

Additional Comments
Genetic Interactions
Statement
Reference

lwr05486 or lwr5 dominantly suppress the nondisjunction phenotype of nodDTW females. nodDTW mei-2181 double homozygous females show 60% X chromosome nondisjunction and 63% 4th chromosome nondisjunction. Oocyte spindles are often frayed or oddly shaped, or multiple spindles are present. These defects are suppressed by lwr05486/+.

Heterozygous females transheterozygous with nebTE8, nebTE12 or nebTE20 are sterile.

Presence of mwra increases the rate of X chromosome nondisjunction seven fold in nodDTW heterozygous females.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Wright.

Comments
Comments

"l(1)TW6cs" has been renamed nodDTW.

External Crossreferences and Linkouts ( 2 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
nod8
nodDTW
Name Synonyms
Dominant Ted Wright
Secondary FlyBase IDs
    References (20)