FlyBase Allele Report: Dmel\nonA[9]

General Information

Symbol

Dmel\nonA⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0013091

Feature type

allele

Associated gene

Dmel\nonA

Associated Insertion(s)

Carried in Construct

Also Known As

nonA^diss, diss

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Krejci et al., 1994)

hypomorphic allele - genetic evidence

(Stanewsky et al., 1993)

Mutagen

ethyl nitrosourea

(Kulkarni et al., 1988)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C7434T. Amino acid replacement: R548C. Mutation is close to the second RRM repeat.

(Rendahl et al., 1996)

Point mutation in a charged region at the 3' end of the nonA open reading frame.

(Rendahl and Hall, 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:16,365,216..16,365,216 [+]

Nucleotide change:

C16365216T

Reported nucleotide change:

C7434T

Amino acid change:

R548C | nonA-PA; R548C | nonA-PB; R548C | nonA-PC; R548C | nonA-PD

Reported amino acid change:

R548C

(Rendahl et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

The full-length nonA protein is produced in nonA⁹ adult males and females. No detectable differences in spatial location were observed between mutant and wild type proteins in adults.

(Rendahl et al., 1992)

Transcripts are detected in heads and bodies of males and females.

(Rendahl et al., 1992)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant males turn at random in an optomotor response assay. Male courtship songs have a long tail in CPP (cycles per pulse) frequency distribution but their modal value is 2.

(Campesan et al., 2001)

Mutants have an abnormal optomotor response. Mutant flies have an abnormal ERG which lacks the transient light-on and light-off components. The average cycles per pulse (CPP) value for the very first pulse of the song burst is significantly higher in mutant males than in control males.

(Sandrelli et al., 2001)

Males exhibit a courtship song abnormality. Males and females exhibit a defect in their ERGs, an absence of light-on and light-off transient spikes.

(Rendahl and Hall, 1996)

Mutant courtship song, optomotor blindness, ERG deficit and decrease in viability.

(Krejci et al., 1994)

Optomotor blind and sing with an aberrant, polycyclic courtship song.

(Rendahl and Hall, 1993)

Aberrant song pulse and defects in responses to visual stimuli.

(Rendahl et al., 1992)

In general short pulse trains (5 pulses or less) of the courtship song are normal in males, but although pulse trains containing more than 5 pulses begin normally, they break into polycyclic, high amplitude pulses. These polycyclic pulses have an amplitude 50-100% higher than wild-type. nonA⁹ does not appear to effect courtship hums. Males exhibit longer than normal mating latencies in their courtship of females. Females may be subnormally receptive to males. Males and females show a marked visual impairment. Males transheterozygous for nonA⁹ and either nonA² or nonA⁵ produce normal courtship songs.

(Kulkarni et al., 1988)

isolated as song mutant

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

nonA⁹ is rescued by nonA^hs.PR

(Rendahl and Hall, 1996)

Partially rescued by

nonA⁹ is partially rescued by Scer\GAL4^nonA.Kpn3/nonA^UAS.cSa

(Sandrelli et al., 2001)

nonA⁹ is partially rescued by Scer\GAL4^nonA.Kpn4/nonA^UAS.cSa

(Sandrelli et al., 2001)

nonA⁹ is partially rescued by Scer\GAL4^nonA.Kpn5/nonA^UAS.cSa

(Sandrelli et al., 2001)

nonA⁹ is partially rescued by Scer\GAL4^nonA.Kpn1/nonA^UAS.cSa

(Sandrelli et al., 2001)

Not rescued by

nonA⁹ is not rescued by Scer\GAL4^nonA.Kpn7/nonA^UAS.cSa

(Sandrelli et al., 2001)

Comments

Heat induced expression of nonA^hs.PR throughout embryonic to pupal development, or during the first five days following eclosion, or during development and early development rescues the visual and song phenotypes.

(Rendahl and Hall, 1996)

Song defects can be rescued by P element mediated transformation of nonA⁺.

(Rendahl et al., 1992)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

109075

nonA⁹ / FM7c

Notes on Origin

Discoverer

Steinlauf.

Comments

Isolated as a courtship song mutant.

(Kulkarni et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

diss

(Krejci et al., 1994, Kulkarni et al., 1988)

nonA⁹

nonA^diss

(Campesan et al., 2001, Sandrelli et al., 2001, Yamamoto and Nakano, 1999, Yamamoto and Nakano, 1998, Rendahl and Hall, 1996, Rendahl et al., 1996, Rendahl and Hall, 1993, Stanewsky et al., 1993, Bernstein et al., 1992, Rendahl et al., 1992, Rendahl and Hall, 1991, Rendahl et al., 1991)

Name Synonyms

dissonance

Secondary FlyBase IDs

References (14)

Report Sections

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