FlyBase Allele Report: Dmel\norpA[P16]

General Information

Symbol

Dmel\norpA^P16

Species

D. melanogaster

Name

FlyBase ID

FBal0013128

Feature type

allele

Associated gene

Dmel\norpA

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Pearn et al., 1996)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C1733T (nucleotide numbering as in FBrf0047660). Amino acid replacement: R361C.

(Pearn et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:4,357,785..4,357,785 [+]

Nucleotide change:

C4357785T

Reported nucleotide change:

C1733T

Amino acid change:

Reported amino acid change:

R361C

(Pearn et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology

(Wang et al., 2008, Hardie et al., 2002)

abnormal visual behavior | recessive

(Scott and Zuker, 1998)

Phenotype Manifest In

photoreceptor

(Scott and Zuker, 1998)

photoreceptor neuron

(Hardie et al., 2002)

Detailed Description

Statement

Reference

norpA³⁵ homozygous adults show extremely slow deactivation kinetics.

(Wang et al., 2008)

The amplitude of quantum bumps in mutant photoreceptors is smaller than wild type (when ATP is present in the intracellular solution during recordings). When ATP is absent from the intracellular solution during recordings, the amplitude of quantum bumps from mutant photoreceptors increases to values approaching wild type.

(Hardie et al., 2002)

The size and shape of the quantum bumps are unaffected, although the latency is significantly different from wild type.

(Scott and Zuker, 1998)

The electroretinogram (ERG) of norpA³⁵ flies shows reduced amplitude and slower response kinetics compared to that of wild-type flies.

(Pearn et al., 1996)

The amplitude response to vapours of all odorants tested in the maxillary palp is not significantly different from wild type. The antennal response is also unaffected.

(Riesgo-Escovar et al., 1995)

intermediate ERG

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

norpA^P16 has abnormal neurophysiology phenotype, suppressible by rdgA¹

(Hardie et al., 2002)

NOT suppressed by

Statement

Reference

norpA^P16 has abnormal neurophysiology phenotype, non-suppressible by mts^XE-2258/mts[+]

(Wang et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

norpA^P16 has photoreceptor neuron phenotype, suppressible by rdgA¹

(Hardie et al., 2002)

Suppressor of

Statement

Reference

norpA^P16 is a suppressor of rhabdomere phenotype of rdgA¹

(Georgiev et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The homozygous norpA³⁵ deactivation defects are not rescued when in combination with mts^XE-2258/+.

(Wang et al., 2008)

norpA³⁵ almost completely suppresses the retinal degeneration seen in rdgA¹ flies.

(Georgiev et al., 2005)

The small amplitude of quantum bumps in norpA³⁵ photoreceptors (seen when ATP is present in the intracellular solution during recordings) is increased in size to near wild-type levels if the flies are also mutant for rdgA¹.

(Hardie et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9049

w^* norpA^P16

Notes on Origin

Discoverer

Pak.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

P16

(Yoon et al., 2004)

norpA³⁵

norpA^P16

(Wang et al., 2008, Georgiev et al., 2005, Hardie et al., 2003, Hardie et al., 2002, Scott and Zuker, 1998, Pearn et al., 1996, Riesgo-Escovar et al., 1995, Pearn et al., 1991)

x16

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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