FlyBase Allele Report: Dmel\oc[2]

General Information

Symbol

Dmel\oc²

Species

D. melanogaster

Name

FlyBase ID

FBal0013200

Feature type

allele

Associated gene

Dmel\oc

Associated Insertion(s)

Carried in Construct

Also Known As

otd^JA101, otd²

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Royet and Finkelstein, 1995)

Mutagen

X ray

(Royet and Finkelstein, 1995, Finkelstein et al., 1990)

Progenitor genotype

Cytology

Description

Small deletion.

(Finkelstein et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

lethal - all die during embryonic stage | recessive

(Royet and Finkelstein, 1995)

some die during embryonic stage | recessive

(Royet and Finkelstein, 1995)

visible

(Royet and Finkelstein, 1995)

Phenotype Manifest In

embryonic antennal segment

(Finkelstein and Perrimon, 1990)

embryonic brain

(Leuzinger et al., 1998)

embryonic brain & commissure

(Adachi et al., 2001)

embryonic head

(Finkelstein et al., 1990)

embryonic protocerebrum

(Adachi et al., 2001, Hirth et al., 1995)

embryonic segment

(Finkelstein et al., 1990)

embryonic ventral epidermis

(Kim and Crews, 1993)

interocellar bristle

(Royet and Finkelstein, 1995)

larval longitudinal connective

(Leuzinger et al., 1998)

lateral ocellus

(Royet and Finkelstein, 1995)

medial ocellus

(Royet and Finkelstein, 1995)

neuropil | embryonic stage

(Finkelstein et al., 1990)

ocellar bristle

(Royet and Finkelstein, 1995)

postocellar bristle

(Royet and Finkelstein, 1995)

presumptive embryonic/larval central nervous system

(Finkelstein et al., 1990)

symmetrical commissure

(Leuzinger et al., 1998)

symmetrical commissure | embryonic stage

(Finkelstein et al., 1990)

Detailed Description

Statement

Reference

The protocerebral brain anlage fails to develop in mutants and the preoral brain commissure is not formed.

(Adachi et al., 2001)

The protocerebral brain anlage fails to develop in homozygous embryos, and the preoral brain commissure is missing or severely reduced. Ubiquitous overexpression of oc^hs.PR in homozygous embryos at stage 7-8 results in restoration of anterior brain morphology in over half the heat shocked embryos. Rescue of the embryonic brain phenotype by overexpression of oc^hs.PR is not possible after stage 8. Ubiquitous overexpression of Hsap\OTX2^hs.PN in homozygous embryos at stage 7-8 results in restoration of anterior brain morphology in 45% of heat shocked embryos. Ubiquitous overexpression of Hsap\OTX1^hs.PN in homozygous embryos at stage 7-8 results in restoration of anterior brain morphology in over one-fifth of heat shocked embryos. Rescue of the embryonic brain phenotype by overexpression of oc^hs.PR, Hsap\OTX1^hs.PN or Hsap\OTX2^hs.PN is not possible after stage 8. Homozygous embryos have deranged connectives and fused commissural axon tracts in the ventral nerve cord. This phenotype can be rescued by ubiquitous overexpression of oc^hs.PR at stage 10-11. The phenotype can be rescued in 100% of cases by ubiquitous overexpression of Hsap\OTX2^hs.PN at stage 10-11. The phenotype can be rescued in over 90% of cases by ubiquitous overexpression of Hsap\OTX1^hs.PN at stage 10-11. Rescue is not seen if oc^hs.PR, Hsap\OTX1^hs.PN or Hsap\OTX2^hs.PN is expressed before stage 10 or after stage 11.

(Leuzinger et al., 1998)

Neuromere b1 is absent or reduced in all embryos.

(Hirth et al., 1995)

Median ocellus is displaced anteriorly and is smaller. The pattern of interocellar and ocellar bristles is disturbed. The distance between the two lateral ocelli and between the two postvertical bristles is increased. Phenotypic series from the strongest to weakest oc allele: oc^db/oc^db > oc¹/oc⁺ > oc^γa1/oc⁺ > oc²/oc⁺ > oc¹/oc¹ > oc^γa1/oc^γa1 > oc²/oc¹ > oc²/oc^γa1.

(Royet and Finkelstein, 1995)

The dorsal arms of the head skeleton are absent or fragmented in mutant embryos. The antennal segment is missing.

(Finkelstein and Perrimon, 1990)

Defects in head development and segmental patterning. Abnormal neuropil. Aberrant commissure formation in each segment. The disappearance of neurons labelled by a P{A92}45C demonstrate that cell death is restricted to identified neurons associated with the midline of the CNS.

(Finkelstein et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

oc² has embryonic brain & commissure phenotype, suppressible by Hror\Otx^hs.PA

(Adachi et al., 2001)

oc² has embryonic brain & commissure phenotype, suppressible by Hsap\OTX2^hs.PN

(Adachi et al., 2001)

oc² has embryonic protocerebrum phenotype, suppressible by Hror\Otx^hs.PA

(Adachi et al., 2001)

oc² has embryonic protocerebrum phenotype, suppressible by Hsap\OTX2^hs.PN

(Adachi et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The embryonic brain defects of oc² animals are partially rescued by Hsap\OTX2^hs.PN or Hror\Otx^hs.PA.

(Adachi et al., 2001)

Complementation and Rescue Data

Partially rescued by

oc² is partially rescued by oc^hs.PR

(Adachi et al., 2001)

oc² is partially rescued by oc^hs.PR

(Leuzinger et al., 1998)

Comments

non-complementing allele

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8676

y¹ sn³ oc² P{neoFRT}19A/FM7c

Notes on Origin

Discoverer

Lefevre.

Comments

Less than 50% of wild type number of ventral epidermal cells expressing P{lacZ}BP28 are evident in mutant embryos.

(Kim and Crews, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Df(1)JA101

(Finkelstein et al., 1990)

l(1)JA101

(Spradling et al., 1994)

oc²

(Sen et al., 2014, Sen et al., 2014)

otd²

(Fichelson et al., 2012, Tahayato et al., 2003)

otd^JA101

(Bridi et al., 2020, Hirth et al., 2003, Adachi et al., 2001, Hartmann et al., 2001, Leuzinger et al., 1998, Goriely et al., 1996, van den Dries et al., 1996, Hirth et al., 1995, Royet and Finkelstein, 1995, Wieschaus et al., 1992, Finkelstein and Perrimon, 1990, Finkelstein et al., 1990)

Name Synonyms

Secondary FlyBase IDs

FBab0000459

References (19)

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