FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\oc9
Open Close
General Information
Symbol
Dmel\oc9
Species
D. melanogaster
Name
FlyBase ID
FBal0013207
Feature type
allele
Associated gene
Dmel\oc
Associated Insertion(s)
Carried in Construct
Also Known As
otdH1
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Younossi-Hartenstein et al., 1997)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      abdominal neuromere

      (Menne et al., 1997)

      embryonic deutocerebrum

      (Younossi-Hartenstein et al., 1997)

      embryonic protocerebrum

      (Younossi-Hartenstein et al., 1997)

      growth cone

      (Klambt et al., 1991)

      larval anterior commissure

      (Klambt et al., 1991)

      larval dorsal VUM motor neuron of abdominal 1 neuromere

      (Klambt et al., 1991)

      larval dorsal VUM motor neuron of abdominal 2 neuromere

      (Klambt et al., 1991)

      larval dorsal VUM motor neuron of abdominal 3 neuromere

      (Klambt et al., 1991)

      larval dorsal VUM motor neuron of abdominal 4 neuromere

      (Klambt et al., 1991)

      larval dorsal VUM motor neuron of abdominal 5 neuromere

      (Klambt et al., 1991)

      larval dorsal VUM motor neuron of abdominal 6 neuromere

      (Klambt et al., 1991)

      larval dorsal VUM motor neuron of abdominal 7 neuromere

      (Klambt et al., 1991)

      larval lateral VUM motor neuron of abdominal 1 neuromere

      (Klambt et al., 1991)

      larval lateral VUM motor neuron of abdominal 2 neuromere

      (Klambt et al., 1991)

      larval lateral VUM motor neuron of abdominal 3 neuromere

      (Klambt et al., 1991)

      larval lateral VUM motor neuron of abdominal 4 neuromere

      (Klambt et al., 1991)

      larval lateral VUM motor neuron of abdominal 5 neuromere

      (Klambt et al., 1991)

      larval lateral VUM motor neuron of abdominal 6 neuromere

      (Klambt et al., 1991)

      larval lateral VUM motor neuron of abdominal 7 neuromere

      (Klambt et al., 1991)

      larval posterior commissure

      (Klambt et al., 1991)

      larval ventral VUM motor neuron of abdominal 1 neuromere

      (Klambt et al., 1991)

      larval ventral VUM motor neuron of abdominal 2 neuromere

      (Klambt et al., 1991)

      larval ventral VUM motor neuron of abdominal 3 neuromere

      (Klambt et al., 1991)

      larval ventral VUM motor neuron of abdominal 4 neuromere

      (Klambt et al., 1991)

      larval ventral VUM motor neuron of abdominal 5 neuromere

      (Klambt et al., 1991)

      larval ventral VUM motor neuron of abdominal 6 neuromere

      (Klambt et al., 1991)

      larval ventral VUM motor neuron of abdominal 7 neuromere

      (Klambt et al., 1991)

      midline glial cell

      (Klambt et al., 1991)

      neuroblast MNB

      (Klambt et al., 1991)

      ventral midline of embryo

      (Menne et al., 1997)
      Detailed Description
      Statement
      Reference

      Many midline neurons are disrupted and mutants exhibit a reduction in the lateral CNS neurones in each abdominal hemineuromere.

      (Menne et al., 1997)

      Embryos lack most protocerebral (P) neuroblasts and some deutocerebral (D) neuroblasts. Most of the anterior (Da) and posterior (Dp) deutocerebral neuroblasts, and some of the central (Dc) deutocerebral neuroblasts are missing. Most or all of the protocerebral Pc4, Pa3-6 and Pp cell groups are missing, while Pc1/2 and Pa1/2 neuroblasts are less or not at all affected. The protocerebrum is strongly reduced in size and there are some defects in the deutocerebrum in late embryos.

      (Younossi-Hartenstein et al., 1997)

      Structures at the ventral midline and CNS development are defective. Posterior commissure is missing in every segment and anterior commissure formation in the thoracic segments is affected. Growth cones that pioneer the posterior commissure do not make the correct pathway choice and grow anteriorly and posteriorly after correct extension. Growth cones that pioneer the anterior commissure do make the correct pathway choice and grow straight toward the midline.

      (Klambt et al., 1991)

      embryonic lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      non-complementing allele

      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements: ibxM72.

      (Kerr et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (12)