FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pll8
Open Close
General Information
Symbol
Dmel\pll8
Species
D. melanogaster
Name
FlyBase ID
FBal0013862
Feature type
allele
Associated gene
Dmel\pll
Associated Insertion(s)
Carried in Construct
Also Known As
pll628
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Hecht and Anderson, 1993)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: S197F.

(Towb et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:27,252,310..27,252,310 [-]
Nucleotide change:

C27252310T

Amino acid change:

S197F | pll-PA; S197F | pll-PB

Reported amino acid change:

S197F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Towb et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pupal lethal when heterozygous with the MBT chromosome. Shows brain tumours when heterozygous with the MBT chromosome. In addition, in pll8/MBT flies, a second eye occurs on one or both sides in 50% of flies.

      (Riede, 2001)

      Stronger dorsalising phenotype at 18oC than 29oC. Homozygotes and heterozygotes with Df(3R)R38.3 have a moderately dorsalised phenotype and a completely dorsalised phenotype when heterozygous with pll16. Heterozygotes produced some dorsalised phenotypes at 29oC when also heterozygous for Df(3R)XM3.

      (Hecht and Anderson, 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      mer-on-314, pll8 has lethal | larval stage phenotype

      (Riede, 2001)

      pll8, tld6 has lethal | pupal stage phenotype

      (Riede, 2001)

      pll8, rigelP has lethal | larval stage phenotype

      (Riede, 2001)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      pll8 mer14 and pll8 rigelP induces neoplasms. spz3/pll8 does not result in neoplasms.

      (Riede, 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weak pll allele.

      (Hecht and Anderson, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pll628
      (Riede, 2001, Towb et al., 2001, Hecht and Anderson, 1993, Tearle and Nusslein-Volhard, 1987)
      pll8
      Name Synonyms
      Secondary FlyBase IDs
        References (6)