FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\polo2
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General Information
Symbol
Dmel\polo2
Species
D. melanogaster
Name
FlyBase ID
FBal0013925
Feature type
allele
Associated gene
Dmel\polo
Associated Insertion(s)
P{}polo2
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Llamazares et al., 1991)
Progenitor genotype
Associated Insertion(s)
P{}polo2
Cytology
Description

Insertion of a 1.6kb P-element.

(Llamazares et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous and hemizygous males die before reaching the third larval instar stage. The testes of polo1/polo2 males show cytological abnormalities during all stages of spermatogenesis. Primary spermatocytes containing less than the wild-type number of 16 cells (usually containing 14 cells of normal size and 1 large cell) are seen. The overall organisation of the spindles of metaphase I cysts is defective; the spindles appear shorter and thicker than wild-type, showing large asters of microtubule bundles. Metaphase II cysts have similar abnormalities. Cysts in the second meiotic division are mostly incomplete and highly disorganised. Onion stage cysts contain a variable number of cells, with variable nuclear and Nebenkern volume.

      (Herrmann et al., 1998)

      Homozygous larval neuroblasts have smaller centrosomes than normal.

      (Logarinho and Sunkel, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      polo2 is rescued by polot10

      (Llamazares et al., 1991)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Karess.

      Comments
      Comments

      All fully viable and fertile revertants of polo2 obtained in a screen were associated with the loss of the P-element that is inserted at 77A3 in polo2.

      (Llamazares et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      polo2
      Name Synonyms
      Secondary FlyBase IDs
        References (4)