FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rec2
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General Information
Symbol
Dmel\rec2
Species
D. melanogaster
Name
FlyBase ID
FBal0014515
Feature type
allele
Associated gene
Dmel\rec
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

A to T transversion that disrupts the splice acceptor site.

(Blanton et al., 2005)

Nucleotide substitution: A?T.

(Blanton et al., 2005)

AG to TG mutation in the conservative splice acceptor site of the single large intron.

(Matsubayashi and Yamamoto, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,824,872..15,824,872 [-]
Nucleotide change:

A15824872T

Reported nucleotide change:

A7761T

Comment:

A to T transversion that disrupts the splice acceptor site.

(Blanton et al., 2005, Matsubayashi and Yamamoto, 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The frequency of region 3 cysts with two pro-oocytes (as assayed by c(3)G staining) in rec1/rec2 females is not significantly different from that seen in wild-type females.

      (Joyce and McKim, 2009)

      rec1/rec2 mutant females show reduction in the overall frequency of crossing over on the second chromosome compared to wild type. The reduction in crossing over in the centromere-proximal interval is more modest than the total reduction in crossing over frequency.

      (Blanton et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      rec2/rec1 is a suppressor of presumptive oocyte phenotype of hdmg7

      (Joyce and McKim, 2009)

      rec2 is a suppressor of presumptive oocyte phenotype of spn-A1

      (Joyce and McKim, 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The high frequency of region 3 cysts containing two pro-oocytes that is seen in hdmg7 homozygous females is suppressed by rec1/rec2.

      The high frequency of region 3 cysts containing two pro-oocytes that is seen in spn-A1 homozygous females is suppressed by rec2.

      (Joyce and McKim, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer

      R.F. Grell & E.E. Generoso, April 1974.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (10)